DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and alpha-Est8

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	172/575 - (29%)
Similarity:	252/575 - (43%)	Gaps:	120/575 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DPLIVEITNGKIRGKD-----NGLYYSYESIPNAEHPTGALRFEAP-QPYSHHWTDVFNATQSPV 81
            |.:|.:...||::|..     ...|||:|.||.|:.|.|.|||:|| :|  .||:||...|....
  Fly    31 DKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEP--EHWSDVKRCTHVRA 93

  Fly    82 ECMQWNQFINENNKLMGDEDCLTVSIY----KPKKPNRSSFPVVVLLHGGAFMFGSGS--IYGHD 140
            :..|.|..:.:   :.|.||||.:::|    .|.:|    .||:|.::||.|..|..|  :|..|
  Fly    94 KPCQVNIVLKQ---VQGSEDCLYLNVYTRELHPHRP----LPVLVWIYGGGFQMGEASRDLYSPD 151

  Fly   141 SIMREGTLLVVKISFGLGPLGFASTGDRHL--PGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLI 203
            .||.|..:||| ||:.||.|||.|..|..|  |||.|||||.:||:|:|:|...|||.||||.:.
  Fly   152 YIMMEHVVLVV-ISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVF 215

  Fly   204 GHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVG-CGHTN---VS 264
            |.||||||.|..:|.:..|.|....|.:||:||.||..........:.|.:..| .|..|   :.
  Fly   216 GESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIF 280

  Fly   265 AELKDCLKS---KPASDIVSAV---RSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGK 323
            |.||.|..|   |.|.||::..   :...:||      |||.:||...|...:.:.|..:::...
  Fly   281 AHLKKCKASSMLKVAEDIITMEERHQRLTMFS------FGPTIEPYLTPHCVIPKSPLEMMRDCW 339

  Fly   324 FAQVPWAVTYTTEDGGYNAAQLL---ERNKLTGESWIDLL-------------------NDRWFD 366
            ...:|..:      ||.:...||   |.||     |.:||                   ..:.|.
  Fly   340 GNSIPMVI------GGNSFEGLLMFPEVNK-----WPELLCQLGDCENLAPQDAHVDEQQRKAFG 393

  Fly   367 WAPYLLFYRD---AKKTIKDMDDLSFDLRQQYLADRRFSVESYWN-VQRMFTDVLFKNSVPSAID 427
            .....|::.|   .:|||.:..||             ||.:.:|: :.|..
  Fly   394 KKVRELYFGDRTPGRKTILEYSDL-------------FSYKYFWHGIHRTL-------------- 431

  Fly   428 LHRKYGKSPVYSFVYDNPTDS---GVGQLLSNRTDVHFGTVHGDDF-FLIFNTAAYRTGIRPDEE 488
            |.|.:......:|:|....||   .:.::::....|. ||.|.||. :|.:|.||.:...|..|.
  Fly   432 LSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVR-GTCHADDLSYLFYNAAAKKLKRRTAEF 495

  Fly   489 VISKKFIGMLEDFALNDKGTLTFGECNFQN----------NVNSKEYQVLRISRN 533
            ...|:.:.|:..||::....:.. .|..:.          :.:.|.:|.|.||.:
  Fly   496 KTIKRLVSMVVHFAISGDPNIPM-VCQDEKEQPRGAWLPISKDDKVFQCLNISHD 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	171/572 (30%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	66/140 (47%)
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	172/575 (30%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	52/109 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440369
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800