DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and alpha-Est9

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	152/546 - (27%)
Similarity:	240/546 - (43%)	Gaps:	113/546 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ADPLIVEITNGKIRG-KDNGL----YYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQSPV 81
            ::..:|..|.|.|:| |...:    |:|:|.||.|:.|.|.||::|||| ...||:|.:.|....
  Fly    29 SEKTVVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQP-PEVWTEVRSCTSQGP 92

  Fly    82 ECMQWNQFINENNKLMGDEDCLTVSIYK----PKKPNRSSFPVVVLLHGGAFMFGSGS--IYGHD 140
            :.:| ..|:.|...  |.||||.:::|.    |.||    .||:|.::||.|.||..|  .|..|
  Fly    93 KPLQ-KHFVFEMTD--GSEDCLYLNVYTKNLYPTKP----MPVMVWIYGGGFQFGEASRECYSPD 150

  Fly   141 SIMREGTLLVVKISFGLGPLGFASTGD-----RHL------------------PGNYGLKDQRLA 182
            .::|| .::|:.|::.|||||   |.|     :|:                  |||.|||||.||
  Fly   151 YLLRE-DVVVISINYRLGPLG---TNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLA 211

  Fly   183 LQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRR 247
            |:|:|.|.:.|||...||.:.|.|||.||.|..::.|....|...||.:|||.|.||.:.. .|.
  Fly   212 LRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTP-QRN 275

  Fly   248 RAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLV----FSYVPFSAFGPVVEPSDAPD 308
            ..:.|....|....|.:.::.:.||:...|:|:.|.....:    ...:.|| ||||:||.....
  Fly   276 WPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFS-FGPVIEPYVTSH 339

  Fly   309 AFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLF 373
            ..:.:.|..::::.....:|..:...:.:|                                ||.
  Fly   340 CVVPKKPIEMMRTAWSNNIPLIIGGVSNEG--------------------------------LLL 372

  Fly   374 YRDAK---KTIKDMDDLSF--------------------DLRQQYLADRRFSVESYWNVQRMFTD 415
            |.:.|   |.:.::||..|                    .|||.|..|:..|:::.....:|.:.
  Fly   373 YSETKTNPKCLNELDDCRFVVPIELNMDRESALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSH 437

  Fly   416 VLFKNSVPSAIDLHRKYGKSP---VYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDF-FLIFNT 476
            ..|...:...:....:|.:|.   :|.|.:|:...:.: ::||....|. ||.||||. :|.:|:
  Fly   438 EYFWFPIYRTVLSRLQYARSAPTYLYRFDFDSKHFNHL-RILSCGKKVR-GTCHGDDLSYLFYNS 500

  Fly   477 AAYRTGIRPDEEVISKKFIGMLEDFA 502
            .|.:......|....::.:|:...||
  Fly   501 LARKLKNHTREYKCIERLVGLWTHFA 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	152/542 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	62/161 (39%)
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	152/542 (28%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	48/129 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440379
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.800