DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-P and CG12869

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	123/518 - (23%)
Similarity:	211/518 - (40%)	Gaps:	104/518 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQSPVECMQW-NQFINENN------KLM 97
            |..|::..||.|:.|...||| ||...|..:.....||.....|.|. |...:|::      .:.
  Fly    50 GAVYAFLGIPYAQAPINELRF-APAKPSSSFNRTLQATTMQPLCPQLANTIYDESSDGSMPRSVS 113

  Fly    98 GDEDCLTVSIYKPKKPNR-SSFPVVVLLHGGAFMFG--SGSIYGHDSIMREGTLLVVKISFGLGP 159
            .|||||.::|:.|:...| ...|:||::.|..|.:.  ...|.|.| :..|| ::||.:.:....
  Fly   114 TDEDCLYLNIWTPESGMRYGKLPIVVIVTGEEFAYDWPRNRINGLD-LAGEG-IVVVSVQYRNNI 176

  Fly   160 LGFASTGDRH--LPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFK 222
            .|:.|.|::|  :||||||.|.::||:||::|...|||.||:|.|:||.:|||...|....||..
  Fly   177 YGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSS 241

  Fly   223 HLAKGAISVSGNAL-------DPWVIQQGGRRRAFELGRIVGCGHTNVS-AELKDCLKSKPASDI 279
            .:.:..:...|..:       ..|:::.|.     .|.:.:||...... .:|..||:.|...|:
  Fly   242 QVKQLVLMSPGPIMRALGQNHQKWIVETGQ-----VLVQKLGCQFEEAQRRQLMGCLRRKSREDL 301

  Fly   280 VSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQ 344
            :.|..|  |:::...|:...|:.|...|   |.:..|      .....|..:..|:.:|.:
  Fly   302 LRAYES--VYNHGNGSSQLGVILPEGLP---LEQRLR------NKTLPPVLLGITSNEGAF---- 351

  Fly   345 LLERNKLTGESWIDLLNDRWFDWAPYLLFYRDAK-------------KTIKDMDDLSFDLRQQYL 396
                           |.|.|.|.|      |:.:             ..::.::.:..:...|..
  Fly   352 ---------------LQDYWLDVA------REGQVALHKYINHTLLPNVMRALESVGEESSTQLA 395

  Fly   397 ADRRFSVESYWN------------VQRMFTDVLFKNSVPSAIDLHRKYGKSPVYSFVYDNPTDSG 449
            |.|    ..|:|            :||:.::.|::......::|   ...:..|::|:|:.....
  Fly   396 AIR----WRYFNGKGEGVSHLLAGMQRLLSESLYELPYSRILEL---LNGTTSYAYVFDHSHSMD 453

  Fly   450 VGQLLSNRTDVHFGTVHGDDFFLIFNTAAY----RTGIRPDEEVISKKFIGMLEDFALNDKGT 508
                :..|.::..|..|..|..|:...:.:    |.....:||.:.:|..|...:|..|...|
  Fly   454 ----MRGRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRKIRGAFANFIKNGNPT 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	123/518 (24%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	47/144 (33%)
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	123/518 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000