DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Gli

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	135/492 - (27%)
Similarity:	221/492 - (44%)	Gaps:	91/492 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ALESEADPLIVEITN-GKIRG-----KDN----GLYYSYES--------------IPNAEHPTGA 57
            :|..|.|..:.  || |:::|     .||    ..|..|.|              ||.|..||..
  Fly   128 SLTLERDVFVT--TNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFE 190

  Fly    58 LRFEAPQPYSHHWTDVFNATQSPVECMQWNQFINENNKLMG-DEDCLTVSIYKPKKPN--RSSFP 119
            .||:.|:  .|....:..|......|.|..::......:|. |||||.:::|.||...  ...:|
  Fly   191 GRFKPPR--VHRGWQLLQAVDFGPACPQPVRYTGATKGIMDMDEDCLYLNVYSPKTGAGVAQKYP 253

  Fly   120 VVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQ 184
            |:|.:|||.|:.|:.:::....:.....::||.:::.||.|||.||||.:.|||||:.||.:||:
  Fly   254 VMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALR 318

  Fly   185 WIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQG---GR 246
            |:..||..|.|..::|.|.|..||||||.|.::....:::.:..|:.||:||..|.:.|.   .:
  Fly   319 WVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQ 383

  Fly   247 RRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFS------AFGPVVE--- 302
            ..:..||:::||. ...|.:|.:||::.         |||.......||      .:|||::
  Fly   384 NTSRVLGQLLGCS-IESSWKLVNCLRTG---------RSFYELGNAEFSPQVGSFPWGPVLDHNF 438

  Fly   303 --PSD-------APD-AFLTEDPRAVIKSGKF-AQVPWAVTYTTEDGGYNAAQ---LLERNKLTG 353
              |.|       ..| .|||:.|..:|::||| ..:.:....||::..:..||   |....:|.|
  Fly   439 TLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDG 503

  Fly   354 ESWIDLLNDRWFDWAPYLLFYRDAKKTIK-------DMDDLSFDLRQQYLADRRFSVESYWNVQR 411
            ..:...:.:..|.: .|.|......:.||       |.::.:. :|.||:              .
  Fly   504 RFFDQKIREHVFRY-NYTLNPNGVYEAIKYIYTFWPDPNNNTI-IRDQYI--------------N 552

  Fly   412 MFTDVLFKNSVPSAIDLHRKYGKSPVYSFVYDNPTDS 448
            |.:|:.::..|...:.|..:. |.|||.:|.:...::
  Fly   553 MLSDLYYRAPVDQMVKLMLEQ-KVPVYMYVLNTTVEA 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	132/483 (27%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	51/134 (38%)
Gli	NP_476602.1	COesterase	134..695	CDD:278561	133/486 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440345
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.740