DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and CG6414

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	157/498 - (31%)
Similarity:	239/498 - (47%)	Gaps:	60/498 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLCLTLLWIAALESEADPLIVEITNGK-IRGK----DNGLYY-SYESIPNAEHPTGALRFEAPQP 65
            |||:.:.|.....|:.  |.|.:::|. :.|:    .||.:. ::..:|.||.|...|||..|.|
  Fly    14 LLCICIQWSDGRNSQC--LHVRLSHGGWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVP 76

  Fly    66 YSHHWTDVFNATQSPVECMQWNQFINENNKLMGDEDCLTVSIYKPKKP-NRSSFPVVVLLHGGAF 129
            .: .|.....|.:....|:|.:.| ..:..|.|.||||.:::|.|::| ...|.||:|..|||.:
  Fly    77 KA-PWEGERLAIKDAPICLQRDPF-RRDMILEGSEDCLYLNVYTPERPRTNGSLPVMVWFHGGGW 139

  Fly   130 MFGSG--SIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAH 192
            ..|||  |.||.|.:: :..:::|..:|.||||||.||.....|||.|||||...|.|::.|||.
  Fly   140 QCGSGISSFYGPDFLL-DHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIAS 203

  Fly   193 FGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWV------IQQGGRRRAFE 251
            |||.|:::.:.|.||||||....:|.|..:.|....|:.||...:||.      :..|   ||.:
  Fly   204 FGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWAQPAHKGVAAG---RATK 265

  Fly   252 LGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPR 316
            |.:|||||:.....|..:||:.|||.|||:::....|:.:.|...|.||||| :...||||..||
  Fly   266 LAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPPVVEP-EHDGAFLTVAPR 329

  Fly   317 AVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYRDAKKTI 381
            ...|.... |:|..|..|.|:|....|.||...:|..|     ...::....|.:|.|
  Fly   330 QAAKPHGL-QLPLMVGATAEEGLLKTAALLNLPQLLAE-----FKSQFEQVLPVVLNY------- 381

  Fly   382 KDMDDLSFDLRQQYLADRRFSVESYW----------NVQRMFTDVLFKNSVPSAIDLHRKYGKS- 435
             |..|   |..:|.:..|   :||::          |.|.: ||::......:.||.:.:...|
  Fly   382 -DHHD---DSVRQTITQR---IESFYFKSGHDYDKANHQNL-TDLISDGWFVAGIDEYLRLRMSQ 438

  Fly   436 ----PVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIF 474
                |.|.:::|:...:...::.....:..:|..|.::...:|
  Fly   439 EDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLF 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	151/479 (32%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	58/135 (43%)
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	150/474 (32%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	59/138 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.960