DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Ces4a

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001099646.1	Gene:	Ces4a / 291955	RGDID:	1307418	Length:	563	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	152/548 - (27%)
Similarity:	244/548 - (44%)	Gaps:	103/548 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LCLTLLW------IAALESEADPLIVEITNGKIRGK-----DNGLYYSYESIPNAEHPTGALRFE 61
            |.|| ||      :.||.:: :||:: ..:|.::||     |..:.. :..:|.::.|.|..||.
  Rat    14 LSLT-LWLVVQTALGALHTK-EPLLI-TKHGILQGKQVHVGDTPIRV-FLGVPFSQPPVGTRRFA 74

  Fly    62 APQPYSHHWTDVFNATQSPVECMQ--WNQ----FINENNK---LMGDEDCLTVSIYKP-KKPNRS 116
            .|:| ...|..:.:||..|..|:|  |.|    ::|...:   |...||||.:::|.| ..|...
  Rat    75 PPEP-PLPWNGIRDATTYPPSCLQESWGQITSMYLNTRKQYEWLHFSEDCLYLNVYAPVLAPGDP 138

  Fly   117 SFPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRL 181
            ..||:|...||||:.||.|.|....:...|.:::|.:.:.||.|||.|||:.|..||:||.||..
  Rat   139 LLPVMVWFPGGAFLVGSASTYEGSELAARGKVVLVFLQYRLGILGFFSTGNSHARGNWGLLDQIA 203

  Fly   182 ALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGR 246
            ||:|:::||..|||.||::.|.|.|||..|....|:....:.|...|||.||.|:....|.....
  Rat   204 ALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLLMSPLAQGLFHQAISQSGTAVLKTFITHDPL 268

  Fly   247 RRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVF---------SYVPFSAFGPVVE 302
            :.|.::..:.||.|.:....:| |||:.||..::...:....|         ..|.|  ..|||:
  Rat   269 KSAKKIAHLAGCDHNSTKIMVK-CLKALPAEKVMLVSKKMTFFRANSHKDPKDIVWF--LSPVVD 330

  Fly   303 PSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDW 367
            ....|     |||..::..|:...||:.:       |.|:|:                    |:|
  Rat   331 GLVFP-----EDPVVLLTRGQVKPVPYLL-------GVNSAE--------------------FEW 363

  Fly   368 A-PYL----LFYRDAKKT-----------IKDMDDLSFDL-RQQYLADRRFSVESY-WNVQR--- 411
            : |:|    |..|...|.           :.::.:....| .::||:|   ::..: |.:.|
  Rat   364 SLPFLMKLQLNQRIMNKNYITKLLWSCSILLNITEEQIPLVAREYLSD---AISHHDWKMFRNHL 425

  Fly   412 --MFTDVLFKNSVPSAIDLHRKYGKSPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIF 474
              :..|..|..:...|...||..| ||||.:.:.:   ...|.::..|:|   |..|||:...:|
  Rat   426 IDLVGDATFVYATLQAARYHRDAG-SPVYLYEFKH---HAPGIIVKPRSD---GADHGDELSYLF 483

  Fly   475 NTAAYRTGIRPDEEVISKKFIGMLEDFA 502
            .:...:...|.:|:..|.:.:....:||
  Rat   484 GSPFSKGSSRGEEKEFSLQMMKYWANFA 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	143/524 (27%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	55/133 (41%)
Ces4a	NP_001099646.1	COesterase	33..554	CDD:395084	145/527 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336368
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840