Protein Alignment Est-P and CES4A

DIOPT Version :9

• Sequence 1: NP_788501.1
• Gene: Est-P / 39393
• FlyBaseID: FBgn0000594
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 171/636 - (26%)
• Similarity: 257/636 - (40%)
• Gaps: 158/636 - (24%)

  Fly     7 LLC--LTLLWIA-----ALESEADPLIVEITNGKIRGKDNGL----YYSYESIPNAEHPTGALRF 60
            :||  |||..:|     ||.::...::.:.  |.::||...:    ...:..:|.:..|.|.|||
Human    27 ILCWSLTLCLMAQTALGALHTKRPQVVTKY--GTLQGKQMHVGKTPIQVFLGVPFSRPPLGILRF 89

  Fly    61 EAPQPYSHHWTDVFNATQSP----------------------------------------VECMQ 85
            ..|:| ...|..:.:||..|                                        ..|:|
Human    90 APPEP-PEPWKGIRDATTYPPGWSLALSPGWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQ 153

  Fly    86 --WNQFIN------ENNK-LMGDEDCLTVSIYKP-KKPNRSSFPVVVLLHGGAFMFGSGSIY-GH 139
              |.|..:      |..| |...||||.:::|.| :.|.....||:|...||||:.|:.|.| |.
Human   154 ESWGQLASMYVSTRERYKWLRFSEDCLYLNVYAPARAPGDPQLPVMVWFPGGAFIVGAASSYEGS 218

  Fly   140 DSIMREGTLLVVKISFGLGPLGF----ASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNI 200
            |...||..:||. :...||..||    ..|.|.|..||:||.||..||:|:::|||.|||.|.|:
Human   219 DLAAREKVVLVF-LQHRLGIFGFLRWRGRTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNV 282

  Fly   201 VLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSA 265
            .|.|.|||..|....::......|...|||.||.||....|.....:.|.::..:.||.| |.:.
Human   283 TLFGQSAGAMSISGLMMSPLASGLFHRAISQSGTALFRLFITSNPLKVAKKVAHLAGCNH-NSTQ 346

  Fly   266 ELKDCLKSKPASDI--VSAVRSFLVFSY------VPFSAFGPVVEPSDAPDAFLTEDPRAVIKSG 322
            .|.:||::...:.:  ||....||..::      :.:| ..|||:....||     ||..::..|
Human   347 ILVNCLRALSGTKVMRVSNKMRFLQLNFQRDPEEIIWS-MSPVVDGVVIPD-----DPLVLLTQG 405

  Fly   323 KFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDW-APYLLFY---RDA--KKTI 381
            |.:.||:                     |.|      :|:..|:| .||::.:   |.|  |:||
Human   406 KVSSVPY---------------------LLG------VNNLEFNWLLPYIMKFPLNRQAMRKETI 443

  Fly   382 KDM-----DDLSFDLRQQYLADRRFSVESY--------WNVQR-----MFTDVLFKNSVPSAIDL 428
            ..|     ..|:....|..|.     ||.|        |.:.|     :..|..|..:.......
Human   444 TKMLWSTRTLLNITKEQVPLV-----VEEYLDNVNEHDWKMLRNRMMDIVQDATFVYATLQTAHY 503

  Fly   429 HRKYGKSPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGI-RPDEEVISK 492
            ||..| .|||.:.:::   ...|.::..|||   |..|||:.:.:|. ..:.||: ...|:.:|.
Human   504 HRDAG-LPVYLYEFEH---HARGIIVKPRTD---GADHGDEMYFLFG-GPFATGLSMGKEKALSL 560

  Fly   493 KFIGMLEDFAL----NDKGTLTFGECNFQNNVNSKEYQVLRISRNACKNEE 539
            :.:....:||.    || |.|   .|..:.|.:.|..|:...:|...|.:|
Human   561 QMMKYWANFARTGNPND-GNL---PCWPRYNKDEKYLQLDFTTRVGMKLKE 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	161/606 (27%)
		Aes	<107..>240	CDD:223730	57/138 (41%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	163/617 (26%)
		Aes	<184..>291	CDD:223730	47/107 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142701
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840