DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Ces1c

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	159/590 - (26%)
Similarity:	254/590 - (43%)	Gaps:	116/590 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LCLTLLW-------IAALESEADPLIVEITNGKIRGKDNGLYYSYE----------SIPNAEHPT 55
            ||: |:|       |.|....:.|.:|:.|.||:.||    |.|.|          .:|.|:.|.
  Rat     3 LCV-LVWASLAACPIWASGHPSSPPVVDTTKGKVLGK----YVSLEGFTQPVAVFLGVPFAKPPL 62

  Fly    56 GALRFEAPQPYSHHWTDVFNATQSPVECMQ---WNQFI-------NENNKLMGDEDCLTVSIYKP 110
            |:|||..|:| :..|:.|.|.|..|..|.|   ..:.:       .||..|...||||.::||.|
  Rat    63 GSLRFAPPEP-AEPWSFVKNTTTYPPMCSQDGVVGKLLADMLSTGKENIPLEFSEDCLYLNIYSP 126

  Fly   111 KKPNRSS-FPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNY 174
            ....::| .||:|.:|||..:.|..|.|...::.....::||.|.:.||..|..||||.|..||:
  Rat   127 ADLTKNSRLPVMVWIHGGGLIIGGASPYSGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSRGNW 191

  Fly   175 GLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPW 239
            ...||..||:|::.|||:|||.||::.:.|.||||.|..:.:|....|:|...|||.||..|...
  Rat   192 AHLDQLAALRWVQDNIANFGGNPDSVTIFGESAGGVSVSVLVLSPLAKNLFHRAISESGVVLTTN 256

  Fly   240 VIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPS 304
            :.::..:..|..:..:.||.:|: ||.:..||:.|..::::.....      :..::...|::
  Rat   257 LDKKNTQAVAQMIATLSGCNNTS-SAAMVQCLRQKTEAELLELTVK------LDNTSMSTVID-- 312

  Fly   305 DAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGY----NAAQLLERNKLTGESWIDLLNDRWF 365
               ...|.:.|..::....|..||:.|.:..::.|:    ....||...::..:....||.
  Rat   313 ---GVVLPKTPEEILTEKSFNTVPYIVGFNKQEFGWIIPTMMGNLLSEGRMNEKMASSLLR---- 370

  Fly   366 DWAPYLLFYRDA-----KKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSA 425
            .::|.|......     :|.::..||.:  .:::.|.|             ||:||.|  .:| |
  Rat   371 RFSPNLNISESVIPAIIEKYLRGTDDPA--KKKELLLD-------------MFSDVFF--GIP-A 417

  Fly   426 IDLHR--KYGKSPVY--------SFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYR 480
            :.:.|  :...:|.|        |||.|....:..|.             |||:.|.:|.|...:
  Rat   418 VLMSRSLRDAGAPTYMYEFQYRPSFVSDQRPQTVQGD-------------HGDEIFSVFGTPFLK 469

  Fly   481 TGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECNFQNNVNSKEY-------QVLRISRNA--CK 536
            .|...:|..:||..:....:||.|       |..|.:...:..||       |:...::.|  .|
  Rat   470 EGASEEETNLSKLVMKFWANFARN-------GNPNGEGLPHWPEYDQKEGYLQIGATTQQAQKLK 527

  Fly   537 NEEYA 541
            .||.|
  Rat   528 GEEVA 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	148/559 (26%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	54/133 (41%)
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	153/568 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910