DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Ces2c

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_663578.1	Gene:	Ces2c / 234671	MGIID:	2385905	Length:	561	Species:	Mus musculus

Alignment Length:	531	Identity:	157/531 - (29%)
Similarity:	256/531 - (48%)	Gaps:	86/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LCLTLLWIAALES-EADPLIVEITNGKIRG-----KDN--GLYYSYESIPNAEHPTGALRF---E 61
            |.|.|:.:...:| ||:| |.....|:|:|     ||.  |: :::..||.|:.|.|.|||   |
Mouse    17 LLLLLIHVQGQDSPEANP-IRNTHTGQIQGSLIHVKDTKAGV-HTFLGIPFAKPPVGPLRFAPPE 79

  Fly    62 APQPYSHHWTDVFNATQSPVECMQWNQFINE----NNKLM-----GDEDCLTVSIYKPKKPNR-S 116
            ||:|    |:.|.:.|..|..|:|....:||    :.|:|     ..||||.::||.|...:. |
Mouse    80 APEP----WSGVRDGTAHPAMCLQNLDMLNEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAHEGS 140

  Fly   117 SFPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRL 181
            :.||:|.:||||.:.|..|::....:.....|:||.|.:.||.|||.||||:|..||:|..||..
Mouse   141 NLPVMVWIHGGALVIGMASMFDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDQHARGNWGYLDQAA 205

  Fly   182 ALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGR 246
            ||:|:::|||||||.||.:.:.|.||||.|....::....:.|..|||..||.||.|.:|.:...
Mouse   206 ALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVALLPDLISETSE 270

  Fly   247 RRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFL 311
            ..:..:.::.||...: |..|..||:.|..::|::..:   ||..:|....|          .|.
Mouse   271 MVSTTVAKLSGCEAMD-SQALVRCLRGKSEAEILAINK---VFKMIPAVVDG----------EFF 321

  Fly   312 TEDPRAVIKSGKFAQVPWAVTYTTEDGGYN------AAQLLERNKLTGESWIDLLNDRWFDWAPY 370
            ...|:.::.|..|..||..:....::.|::      :||:::  .:|.|:...:|.|.    |..
Mouse   322 PRHPKELLASEDFHPVPSIIGVNNDEFGWSIPVVMGSAQMIK--GITRENLQAVLKDT----AVQ 380

  Fly   371 LLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVL--FKNSVPSAIDLHRKYG 433
            ::.       ..:..||   |.::|:.|    .|....:|..||:::  |...:|:....|.:..
Mouse   381 MML-------PPECSDL---LMEEYMGD----TEDAQTLQIQFTEMMGDFMFVIPALQVAHFQRS 431

  Fly   434 KSPVYSFVYDNPTDSGVGQLLSNRTDV---HFGTVHGDDFFLIFNTAAYRTGIRPD----EEVIS 491
            .:|||.:.:.:|.        |...||   |....|.|:...:|  |::..|::.|    ||::|
Mouse   432 HAPVYFYEFQHPP--------SYFKDVRPPHVKADHADEIPFVF--ASFFWGMKLDFTEEEELLS 486

  Fly   492 KKFIGMLEDFA 502
            ::.:....:||
Mouse   487 RRMMKYWANFA 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	150/512 (29%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	59/133 (44%)
Ces2c	NP_663578.1	COesterase	31..540	CDD:278561	153/517 (30%)
		Aes	<130..>233	CDD:223730	47/102 (46%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832651
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840