DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Ces2b

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_937814.1	Gene:	Ces2b / 234669	MGIID:	2448547	Length:	556	Species:	Mus musculus

Alignment Length:	533	Identity:	148/533 - (27%)
Similarity:	241/533 - (45%)	Gaps:	90/533 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLCLTLLWIAALESEADPLIVEITN---GKIRG-----KDN--GLYYSYESIPNAEHPTGALRF- 60
            ||...||.:..::.:..|....|.|   |::||     ||.  |: :::..||.|:.|.|.|||
Mouse    13 LLFGLLLLLGHVQGQDSPEASPIRNTHTGQVRGSLVHVKDTKAGV-HTFLGIPFAKPPVGPLRFA 76

  Fly    61 --EAPQPYSHHWTDVFNATQSPVECMQWNQFINENNKL-----MGDEDCLTVSIYKPKKPNR-SS 117
              |||:|    |:.|.:.|..|..|:| |..:.:..||     ...||||.::||.|...:. |:
Mouse    77 PPEAPEP----WSGVRDGTAHPAMCLQ-NLGVMKEIKLKLPPVSTSEDCLYLNIYTPAHAHEGSN 136

  Fly   118 FPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLA 182
            .||:|.:|||..:.|..|:|....:.....|:||.|.:.||.|||.||||:|..||:|..||..|
Mouse   137 LPVMVWIHGGGLVAGMASMYDGSLLAAIEDLVVVTIQYRLGVLGFFSTGDQHARGNWGFLDQVAA 201

  Fly   183 LQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRR 247
            |:||::|||||||.||.:.:.|.||||.|....::....|.|..|||..||.||.|::|......
Mouse   202 LRWIQQNIAHFGGKPDRVTIFGESAGGTSVSSHVVSPMSKGLFHGAIMESGVALLPYLITDTSEM 266

  Fly   248 RAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVE--PSDAPDAF 310
            .:..:.::.||...: |..|..||:.|..::|:               |...:|:  |:.....|
Mouse   267 VSTTVAKLSGCEAMD-SEALVRCLRGKSEAEIL---------------AINKLVQMIPAVVDGEF 315

  Fly   311 LTEDPRAVIKSGKFAQVPWAVTYTTEDGGY------NAAQLLERNKLTGESWIDLLNDRWFDWAP 369
            ....|:.::.|..|..||..:....::.|:      .:||.::  ::|.|:...:|
Mouse   316 FPRHPKELLASEDFHPVPSIIGVNNDEFGWTIPVVMGSAQTIK--EITRENLQAVL--------- 369

  Fly   370 YLLFYRDAKKTIKDM------DDLSFDLRQQYLADRRFSVESYWNVQRMFTDVL--FKNSVPSAI 426
                    |.|...:      .||   |.::|:.|    .|....:|..||:::  |...:|:..
Mouse   370 --------KNTTAQLMLPPECSDL---LMEEYMGD----TEDAQTLQIQFTEMMEDFMFVIPALQ 419

  Fly   427 DLHRKYGKSPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAY--RTGIRPDEEV 489
            ..:.:...:.||.:.:.:...|     |.:....|....|.|:...:|....:  :......|::
Mouse   420 VAYFQRSHASVYFYEFQHQIAS-----LKDVRPTHVKADHADEIPFVFGYFFWDMKLDFTEGEKL 479

  Fly   490 ISKKFIGMLEDFA 502
            :|::.:....:||
Mouse   480 LSRRMMKYWANFA 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	143/514 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	61/133 (46%)
Ces2b	NP_937814.1	COesterase	34..535	CDD:365897	143/512 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840