DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Ces1f

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_659179.1	Gene:	Ces1f / 234564	MGIID:	2142687	Length:	561	Species:	Mus musculus

Alignment Length:	556	Identity:	155/556 - (27%)
Similarity:	234/556 - (42%)	Gaps:	115/556 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LTLLWIAALE------SEADPLIVEITNGKIRGKD-NGLYYS-----YESIPNAEHPTGALRFEA 62
            |:.|::.:|.      :.:.|.:|:..:||:.||. |...:|     :..||.|:.|.|:|||..
Mouse     3 LSTLFLVSLATCVICGNPSSPPVVDTAHGKVLGKHVNVEGFSQPVAVFLGIPFAKPPLGSLRFAP 67

  Fly    63 PQPYSHHWTDVFNATQSPVECMQ---WNQFINE---NNK----LMGDEDCLTVSIYKPKKPNRSS 117
            ||| :..|:.|.|||..|..|.|   ..|.:|:   |.|    |...||||.::||.|...:::|
Mouse    68 PQP-AEPWSSVKNATTYPPMCSQDAARGQAVNDLITNRKEKIHLEFSEDCLYLNIYTPADFSKNS 131

  Fly   118 -FPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRL 181
             .||:|.:|||....|..|.:...::.....::||.|.:.|...||.||||.|..||:|..||..
Mouse   132 RLPVMVWIHGGGLKLGGASSFDGRALSAYENVVVVAIQYRLSIWGFFSTGDEHSRGNWGHLDQVA 196

  Fly   182 ALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGR 246
            ||.|::.|||:|||.|.::.:.|.||||.|..:.:|....|:|...|||.||.|..|.:..:..|
Mouse   197 ALHWVQDNIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDVR 261

  Fly   247 RRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFL 311
            ....::....|| .|..||.:..|::.|...:::..:....::.   .|..|    .:...|.|:
Mouse   262 PITEQIAVTAGC-KTTTSAVIVHCMRQKTEEELLEIMHKLNLYK---LSLQG----DTKNSDQFV 318

  Fly   312 T---------EDPRAVIKSGKFAQVPWAVTYTTEDGGY------------------NAAQLLER- 348
            |         :||:.::....|..||:.|....::.|:                  .|..|||:
Mouse   319 TSVLDGVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMTGFLPADVKLDKKKAIALLEQF 383

  Fly   349 NKLTGESWIDLLNDRWFDWAPYLLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMF 413
            ..:||              .|..:.....:|..|..||.. .:|:              .|....
Mouse   384 ASMTG--------------IPEDIIPVAVEKYTKGSDDPD-QIRE--------------GVLDAM 419

  Fly   414 TDVLFKNSVPSAIDL--HRKYGKSPVYSFVYD-NPTDSG-------VGQLLSNRTDVHFGTVHGD 468
            .||.|  .|||.|..  ||..| :|.|.:.|. .|:.|.       ||.             |.|
Mouse   420 GDVAF--GVPSVIVSRGHRDTG-APTYMYEYQYYPSFSSPQRPKNVVGD-------------HAD 468

  Fly   469 DFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALN 504
            |.:.:|.....|.|...:|..:||..:....:||.|
Mouse   469 DVYSVFGAPILREGASEEEINLSKMVMKFWANFARN 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	151/534 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	54/133 (41%)
Ces1f	NP_659179.1	COesterase	24..545	CDD:278561	151/535 (28%)
		Aes	<121..>225	CDD:223730	42/103 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832794
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840