Protein Alignment Est-P and NLGN1

DIOPT Version :9

• Sequence 1: NP_788501.1
• Gene: Est-P / 39393
• FlyBaseID: FBgn0000594
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 164/580 - (28%)
• Similarity: 235/580 - (40%)
• Gaps: 159/580 - (27%)

  Fly    21 EADPLIVEITN-GKIRGKDN-------GLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNAT 77
            :.|||:.  || |||||...       |....:..:|.|..|||..||:.|:|.| .|:|:.|||
Human    50 DVDPLVA--TNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPS-PWSDIRNAT 111

  Fly    78 QSPVECMQ--------------WNQFINENNKLMG-----DEDCLTVSIYKP-------KKPN-- 114
            |....|.|              |  |.|..:.:..     .||||.::||.|       ||..
Human   112 QFAPVCPQNIIDGRLPEVMLPVW--FTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDD 174

  Fly   115 ------------RSS---FPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFAS 164
                        |.|   .||:|.:|||::|.|:|::|....:...|.::|:.:::.||.|||.|
Human   175 LGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLS 239

  Fly   165 TGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKG-- 227
            |||:...|||||.|...||:|..:||..|||.|..|.:.|..|||:..:|..|    .|.::|
Human   240 TGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTL----SHYSEGNR 300

  Fly   228 -----------AISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVS--AELKDCLKSKPASDI 279
                       ||:.||.||..|.:.....:.|..|...|||   |||  .||.:||:.||..::
Human   301 WSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGC---NVSDTVELVECLQKKPYKEL 362

  Fly   280 V----SAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGY 340
            |    ...|..:        |||||::....||     ||:.:::.|:|......:       |.
Human   363 VDQDIQPARYHI--------AFGPVIDGDVIPD-----DPQILMEQGEFLNYDIML-------GV 407

  Fly   341 NAAQLLE--RNKLTGESWIDLLNDRWFDWA-----PYLLFYRDAKKTIKDMDDLSFDLRQQYL-- 396
            |..:.|:  .|.:..:..|...:   ||:|     ..|..|.:.|..:::      .::..|.
Human   408 NQGEGLKFVENIVDSDDGISASD---FDFAVSNFVDNLYGYPEGKDVLRE------TIKFMYTDW 463

  Fly   397 ADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPV--YSFVYDNPTDSGVGQLLSNRTD 459
            |||.........:..:|||..:.....:..|||..:| ||.  |:|.:...||         :..
Human   464 ADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFG-SPTYFYAFYHHCQTD---------QVP 518

  Fly   460 VHFGTVHGDDFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECNFQNN 519
            ......|||:       ..|..||         ..||..|.|           .|||..|
Human   519 AWADAAHGDE-------VPYVLGI---------PMIGPTELF-----------PCNFSKN 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	161/575 (28%)
		Aes	<107..>240	CDD:223730	58/169 (34%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	163/577 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142634
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740