DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Ces2e

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	145/526 - (27%)
Similarity:	229/526 - (43%)	Gaps:	82/526 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LTLLWIAALESEADPLIVEITNGKIRG-----KD--NGLYYSYESIPNAEHPTGALRFEAPQPYS 67
            |.||:......::...|.....|::||     ||  :|: :::..||.|:.|.|.|||..|:| .
  Rat    17 LLLLFCQVQGQDSASPIRNTHTGQVRGSFVHVKDTKSGV-HTFLGIPFAKPPIGPLRFAPPEP-P 79

  Fly    68 HHWTDVFNATQSPVECMQWNQFIN-ENNKL-------MGDEDCLTVSIYKPKKPNR-SSFPVVVL 123
            ..|:.|.:.|..|..|:|....:| ||.|:       ...||||.:|||.|...:: |:.||:|.
  Rat    80 EPWSGVRDGTSHPAMCLQNIDGLNLENLKIKMSRSPVSMSEDCLYLSIYTPAHTHKDSNLPVMVW 144

  Fly   124 LHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKK 188
            :|||...:|..|.|....:.....::||.|.:.||.|||.||||.|..||:|..||..||:|:::
  Rat   145 IHGGGLCWGMASTYDGSMLAAIEDVVVVTIQYRLGILGFFSTGDEHARGNWGYLDQVAALRWVQQ 209

  Fly   189 NIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELG 253
            ||.||||.||.:.:.|.||||.|....::....:.|..|||..||.||.|.:|..........:.
  Rat   210 NIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVALLPNLISNTSEVIYTMVA 274

  Fly   254 RIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAV 318
            .:.||...: |..|..||:.|...::: |:.:.:       .....||:     ..||...|..:
  Rat   275 NLSGCEPVD-SEALMSCLREKSEEEML-AINNIV-------RTISGVVD-----GKFLPRHPLEL 325

  Fly   319 IKSGKFAQVPWAVTYTTEDGGYNAAQL------LERNKLTGESWIDLLNDRWFDWAPYLLFYRDA 377
            :.|..|..||..:...:::.|:....|      .|.|:.|..:.:
  Rat   326 LASVDFHPVPSIIGINSDEYGWIIPMLHPDSTMKEINRETMRAVL-------------------- 370

  Fly   378 KKTIKDM------DDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSP 436
            |.|...|      .||   |.::|:.|...|.........|..|.:|  .:|:....|.:...:|
  Rat   371 KNTAVQMMLPPECSDL---LMEEYMGDTEDSKTLQIQFNEMMGDFIF--VIPALQVAHFQRSHAP 430

  Fly   437 VYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDF-----FLIFNTAAYRTGIRPDEEVISKKFIG 496
            ||.:.:.:.::     .|.:....|....|||:.     :|.::.....|   .:|:::|:|.|.
  Rat   431 VYFYEFQHQSN-----FLKDIRPPHVKADHGDELPYVIGYLFWDMKFVFT---EEEKLLSRKMIK 487

  Fly   497 MLEDFA 502
            ...:||
  Rat   488 YWANFA 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	142/510 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	57/133 (43%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	142/513 (28%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	45/102 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336178
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840