DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and cest-31

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_504692.3	Gene:	cest-31 / 187304	WormBaseID:	WBGene00019653	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	129/554 - (23%)
Similarity:	219/554 - (39%)	Gaps:	122/554 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PL--IVEITNGKIRGK----DNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQSPVE 82
            ||  ::..|.|.::|.    .|...:.|..||.|:.|.|.|||:.|.. :..||:..:.|:....
Worm    12 PLLNVLNSTCGPVQGNLYRHGNEEVHGYLGIPYAQPPIGILRFKKPVS-ADVWTETRDCTKYGPR 75

  Fly    83 C----MQWNQFINENNKLMGDEDCLTVSIYKPKKPNRSS--FPVVVLLHGGAFMFGSGSIYGHDS 141
            |    |.:......|..:..:.:||:::::.|:...:.|  .||::.:|||.|...:...|...|
Worm    76 CPPSGMLYENLQLPNTDIPDEANCLSLNVFCPQWEIKQSAKHPVMIFIHGGGFELSASKDYCDYS 140

  Fly   142 IMREGTL-----LVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIV 201
            :  .|||     :||.:::.:|.|||.:|||....||:||.|..|||:|:..:|:.|||.|.|:.
Worm   141 L--SGTLPLKDVIVVTVNYRVGALGFLTTGDDSCRGNFGLWDLTLALKWVSTHISSFGGDPKNVT 203

  Fly   202 LIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQ----------QGGRRRAFELGRIV 256
            |.|.|||...|.|..|....:.|....|.:||:|..|:.|:          :..|.|.|.
Worm   204 LFGQSAGAVCADLLNLSPYSRDLFHKLIIMSGSAHVPFAIRTEENQALVCMEYARSRGFS----- 263

  Fly   257 GCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKS 321
            |.|    ||||.:..::.|...::.........|          ::.|.||:.
Worm   264 GSG----SAELLEFFENLPIEKLLEKTGLKHTVS----------IDLSFAPNL------------ 302

  Fly   322 GKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGES--WIDLLNDRWFDWAPYLLFYRDAKKTIKDM 384
                           ||.:....|.|..:.|.:.  .:.::.|...     :..:.|...|..:
Worm   303 ---------------DGDFFPKPLEELRRETRKKPVIVGMMEDEGL-----ITAFADGDFTTCE- 346

  Fly   385 DDLSFDLRQQYLADRRFSVESYWNVQR----MFTDVLFKNSVPSAIDL--HRKYGK--------- 434
            ::....:..:|..|   .||:..|||:    .:|:...::.....:|.  |..|..
Worm   347 ENFKRRVESEYRGD---VVENPENVQKNIMNFYTNYCDESEERKLVDYIGHSVYNAGVLLSAESL 408

  Fly   435 ----SPVYSFVYD--NPTDSG-VGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPDEEVISK 492
                :.||.:|:|  ||...| ||.::..:     |..|..:...|.....|......::::...
Worm   409 ARAGNCVYFYVFDFWNPDGFGPVGSIVPFK-----GAAHCSELRYIIGEGVYSKFDANEKDLKMM 468

  Fly   493 KFI-GMLEDFALNDKGTLTFGECNFQNNVNSKEY 525
            ::: .|..:||       .:|..|.....|.:.|
Worm   469 EYMTTMFTNFA-------KYGNPNIPGVTNWETY 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	127/550 (23%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	51/139 (37%)
cest-31	NP_504692.3	COesterase	16..522	CDD:278561	127/550 (23%)
cest-31	NP_504692.3	Aes	<112..>211	CDD:223730	40/100 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810