DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and cest-13

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_741921.1	Gene:	cest-13 / 181493	WormBaseID:	WBGene00010116	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	559	Identity:	133/559 - (23%)
Similarity:	219/559 - (39%)	Gaps:	131/559 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CLTLLWIAALESEADP---LIVEITNGK--IRGKDNGLYYSYESIPNAEHPTGALRFEAPQPYSH 68
            ||.||..|::  .|||   :.|:..||.  |||..:....|:..|..|:.|.|..||.|.:
Worm     8 CLLLLHFASV--LADPTYDVTVQTPNGSATIRGIQHTYGTSFRGIRYAQPPVGLFRFGAAR---- 66

  Fly    69 HWTDVFNATQSP---VECMQWNQFINENNKLMGDEDCLTVSIYKPKKPNRSS-FPVVVLLHGGAF 129
                    ...|   ||...:.....:.:.....||||.:::|.|....::| .||.|.:|||.|
Worm    67 --------RLDPVGLVEAQAYGNICVQGDGRTSHEDCLFINVYTPNNVTQASKLPVYVYIHGGGF 123

  Fly   130 MFGSGSIYG--HDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAH 192
            :.|.|::..  :.:::.:|.:::|.|::.|||.||.||.....|||:.:.|...||.|:::.|:.
Worm   124 VEGGGNMGAGIYPNLVNKGPIVMVSINYRLGPFGFFSTRQMTAPGNWAISDWIEALNWVQRYISF 188

  Fly   193 FGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAF--ELGRI 255
            |||.|:.:.:.|.|:|..:.....|....|:|.|.:|..||:|....|:....:.|:.  :|...
Worm   189 FGGDPNRVTIGGQSSGAEAVSTLTLTPLAKNLFKQSIHESGSAFGAAVMSYSEKTRSTSKQLSIK 253

  Fly   256 VGCGHTN------VSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTED 314
            :||..::      ....:..||::.....||:|..|.                |..
Worm   254 LGCATSDQWDNGQSFGTILTCLRNVTYDKIVAADNSL----------------PGH--------- 293

  Fly   315 PRAVIKSGKFAQVPWAVT----YTTEDGGYNAAQL-LERNKLTGESWIDLLNDRWFDWAPYLLFY 374
                       ::.|::.    |.|:...|.|.|. .::|.|.|:     ::|.|..|....:.:
Worm   294 -----------RMKWSIVQDNKYLTQRLEYLALQRDPKKNVLIGD-----VHDEWLGWEMNNVLH 342

  Fly   375 --RDAKKTIKDM-DDLS-------FDLRQQYL--ADRRFSVESYWNVQRMFTDVLFKNSVPSAID 427
              ..:..|...| ||||       :|.:|..|  ||.::.....|      ||           |
Worm   343 NINSSHNTAHQMRDDLSGSYEMTYWDNKQSVLVAADNKYINNQGW------TD-----------D 390

  Fly   428 LHRKYGKSPVY---SFVYDNPT--DSGVGQLLSNR-----------------TDVHF-GTVHGDD 469
            .||::....:.   ..|:..||  |:...|.:.|.                 ||..| |..|..:
Worm   391 NHREWEARRIQLWSEMVFIGPTLRDAAYFQYMKNNVYLYSLDWLSPPALPLVTDPLFRGCEHTWE 455

  Fly   470 FFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALNDKGT 508
            ...||:|:.........:|::...|.....:|.:....|
Worm   456 LQYIFSTSCNGFTCTAQDEILRNYFTTTWLNFIIGGNPT 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	125/539 (23%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	45/135 (33%)
cest-13	NP_741921.1	Abhydrolase	22..510	CDD:304388	125/543 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010