Protein Alignment Est-P and cest-13

DIOPT Version :10

• Sequence 1: NP_788501.1
• Gene: Est-P / 39393
• FlyBaseID: FBgn0000594
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_741921.1
• Gene: cest-13 / 181493
• WormBaseID: WBGene00010116
• Length: 548
• Species: Caenorhabditis elegans
• Alignment Length: 559
• Identity: 133/559 - (23%)
• Similarity: 219/559 - (39%)
• Gaps: 131/559 - (23%)

  Fly     9 CLTLLWIAALESEADP---LIVEITNGK--IRGKDNGLYYSYESIPNAEHPTGALRFEAPQPYSH 68
            ||.||..|::  .|||   :.|:..||.  |||..:....|:..|..|:.|.|..||.|.:
 Worm     8 CLLLLHFASV--LADPTYDVTVQTPNGSATIRGIQHTYGTSFRGIRYAQPPVGLFRFGAAR---- 66

  Fly    69 HWTDVFNATQSP---VECMQWNQFINENNKLMGDEDCLTVSIYKPKKPNRSS-FPVVVLLHGGAF 129
                    ...|   ||...:.....:.:.....||||.:::|.|....::| .||.|.:|||.|
 Worm    67 --------RLDPVGLVEAQAYGNICVQGDGRTSHEDCLFINVYTPNNVTQASKLPVYVYIHGGGF 123

  Fly   130 MFGSGSIYG--HDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAH 192
            :.|.|::..  :.:::.:|.:::|.|::.|||.||.||.....|||:.:.|...||.|:::.|:.
 Worm   124 VEGGGNMGAGIYPNLVNKGPIVMVSINYRLGPFGFFSTRQMTAPGNWAISDWIEALNWVQRYISF 188

  Fly   193 FGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAF--ELGRI 255
            |||.|:.:.:.|.|:|..:.....|....|:|.|.:|..||:|....|:....:.|:.  :|...
 Worm   189 FGGDPNRVTIGGQSSGAEAVSTLTLTPLAKNLFKQSIHESGSAFGAAVMSYSEKTRSTSKQLSIK 253

  Fly   256 VGCGHTN------VSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTED 314
            :||..::      ....:..||::.....||:|..|.                |..
 Worm   254 LGCATSDQWDNGQSFGTILTCLRNVTYDKIVAADNSL----------------PGH--------- 293

  Fly   315 PRAVIKSGKFAQVPWAVT----YTTEDGGYNAAQL-LERNKLTGESWIDLLNDRWFDWAPYLLFY 374
                       ::.|::.    |.|:...|.|.|. .::|.|.|:     ::|.|..|....:.:
 Worm   294 -----------RMKWSIVQDNKYLTQRLEYLALQRDPKKNVLIGD-----VHDEWLGWEMNNVLH 342

  Fly   375 --RDAKKTIKDM-DDLS-------FDLRQQYL--ADRRFSVESYWNVQRMFTDVLFKNSVPSAID 427
              ..:..|...| ||||       :|.:|..|  ||.::.....|      ||           |
 Worm   343 NINSSHNTAHQMRDDLSGSYEMTYWDNKQSVLVAADNKYINNQGW------TD-----------D 390

  Fly   428 LHRKYGKSPVY---SFVYDNPT--DSGVGQLLSNR-----------------TDVHF-GTVHGDD 469
            .||::....:.   ..|:..||  |:...|.:.|.                 ||..| |..|..:
 Worm   391 NHREWEARRIQLWSEMVFIGPTLRDAAYFQYMKNNVYLYSLDWLSPPALPLVTDPLFRGCEHTWE 455

  Fly   470 FFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALNDKGT 508
            ...||:|:.........:|::...|.....:|.:....|
 Worm   456 LQYIFSTSCNGFTCTAQDEILRNYFTTTWLNFIIGGNPT 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	125/539 (23%)
cest-13	NP_741921.1	alpha/beta hydrolases	24..526	CDD:473884	125/541 (23%)