Protein Alignment Est-P and cest-19

DIOPT Version :10

• Sequence 1: NP_788501.1
• Gene: Est-P / 39393
• FlyBaseID: FBgn0000594
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_509187.4
• Gene: cest-19 / 180973
• WormBaseID: WBGene00020125
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 569
• Identity: 163/569 - (28%)
• Similarity: 243/569 - (42%)
• Gaps: 89/569 - (15%)

  Fly     7 LLCLTLLW----IAALESEADPLIVEITNGKIRGK----DNGLYYSYESIPNAEHPTGALRFEAP 63
            ||...:||    :........|..:.:.:|.|||:    |...|..::.||.|..|.|.|||:.|
 Worm     4 LLSSFILWWHSHLTISTRHISPFELRVNSGAIRGERLLTDGQDYSVFKGIPFAMPPVGYLRFQMP 68

  Fly    64 QPYSHHWTDVFNATQSPVECMQWNQFINENNKLMGD---------EDCLTVSIYKPK--KPNRSS 117
            :..: .|..|.||||....||   |.|:||:  .|:         ||||.::::.|.  :....:
 Worm    69 KEPA-KWRGVMNATQYSAMCM---QNIDEND--AGEPERYVAHVSEDCLYLNVFSPTPYQYTNDT 127

  Fly   118 FPVVVLLHGGAFMFGSGSIYGHDSIMR---EGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQ 179
            :||:|.:|||.|..||||.....:|:.   ...::.|..::.|||||||||||..||||.||.||
 Worm   128 YPVIVFIHGGRFQTGSGSDIPQRAILSNFVSRKIVFVTFNYRLGPLGFASTGDSVLPGNIGLWDQ 192

  Fly   180 RLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQG 244
            ..||:|:|.|...|||.|.||:|:||..|.|||.|..|....:.|.:..:.:||:||.|.|::..
 Worm   193 IWALKWVKANAEVFGGDPSNILLMGHGTGAASASLLALSPRAEGLFQKVLLMSGSALQPGVVRNT 257

  Fly   245 GRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDA 309
            .....:.:....||...| |:||.||.:.:...:|....|    ..:..:..|.|::   |....
 Worm   258 QVNATWNMNDRFGCRAFN-SSELLDCARKRSKEEIFQYKR----LHFDDYEEFVPII---DGVGG 314

  Fly   310 FLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFY 374
            .|.|.|..:....:  :.|..:..|.::.......|.|::          ||.....|
 Worm   315 ILPEPPEQLTLHRR--KTPIVIGTTKDESSLRILLLNEKD----------LNFSSITW------- 360

  Fly   375 RDAKKTIKDMDDLSFDLRQQY-LADRRFSVESYW-NVQRMFTDVLFKNSV----------PSAID 427
             :..:|:.|...|.|...|.: |..:....|..| .|...|.:.:..||:          ..|..
 Worm   361 -ENGETLADNLTLGFKQFQNHRLISQGCKSEYVWTQVDPSFPESVLFNSLLKMYSHFWYDAPASQ 424

  Fly   428 LHRKYGKS--PVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPD---- 486
            |...|.|.  |||.:.:|:        :..|..|:. ...||.|...|||........|.|
 Worm   425 LATYYLKHDLPVYLYSFDH--------ISENFYDID-RAFHGVDKLHIFNVTPRFLNKRKDMNWQ 480

  Fly   487 -EEVISKKFIGMLEDFALNDKGTLTFGECNFQNN---VNSKEYQVLRIS 531
             ::.:.:.|..::.:|||  .||.|.....|..|   ..:||...|.|:
 Worm   481 LDQRVVEIFSELVANFAL--YGTPTHENDGFSFNWTSTTAKELSYLSIT 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	158/546 (29%)
cest-19	NP_509187.4	alpha/beta hydrolases	24..544	CDD:473884	159/549 (29%)