Protein Alignment Est-P and cest-26

DIOPT Version :9

• Sequence 1: NP_788501.1
• Gene: Est-P / 39393
• FlyBaseID: FBgn0000594
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_001368609.1
• Gene: cest-26 / 180715
• WormBaseID: WBGene00017478
• Length: 585
• Species: Caenorhabditis elegans
• Alignment Length: 575
• Identity: 153/575 - (26%)
• Similarity: 230/575 - (40%)
• Gaps: 121/575 - (21%)

  Fly    27 VEITNGKIRG-----KDNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNAT----QSPVE 82
            |...||.:.|     .|:.....:..||.|:.|.|.|||:.|: ::..|..|....    ::|..
 Worm    44 VRTRNGLVEGFRIKIDDDREVDMFLGIPFAKAPVGDLRFKNPE-HTEDWDGVKKCVRFGPRAPQA 107

  Fly    83 CMQWNQFINENNKLMGDEDCLTVSIYKP----KKPNRSSFPVVVLLHGGAFMFGSGSIYGHDSI- 142
            ...|.:|.....|   .||||.::::.|    ::.:....||:|.:|||.|:..|...||.:.|
 Worm   108 DFFWERFTLGVGK---SEDCLYLNVFSPTWKAEEVSNGLHPVMVYVHGGGFLIDSAVKYGDEGIA 169

  Fly   143 ---MREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIG 204
               .|.| ::||.|.:.||.|||.||||:..|||.||.|..:||||::.|:..|||.|..:.:.|
 Worm   170 KYLCRHG-VVVVTIQYRLGLLGFFSTGDQVCPGNLGLWDMTMALQWVRDNVHAFGGDPRKVTVFG 233

  Fly   205 HSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAEL-- 267
            .||||.|..|..|....:.|....:.::||....|  ...|:.|.           .|...|.
 Worm   234 QSAGGVSVDLLSLSPHSRDLFHQVVPMAGNGECEW--STVGKNRL-----------VNACREFAY 285

  Fly   268 KDCLKSKPASDIVSAVRSFLVF----------------SYVPFSAFG----PVV--EPSDAPDAF 310
            :.|...|.|.| .:|..|.|.|                ..|..|..|    ||:  :|||    |
 Worm   286 RKCWDEKQARD-ENASESMLEFLRTRKEREFEKRLLTRKGVDVSKIGLDLAPVIGSKPSD----F 345

  Fly   311 LTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYR 375
            |   |:::.:..|.|.....:..|.|..|...|.|       |.|..|   ::..|....||.
 Worm   346 L---PKSIEELRKEAPKKNIMVGTCEHEGLLFASL-------GPSNFD---EKGIDKLLALLI-- 395

  Fly   376 DAKKTIKDMDDLSFDLRQQYLA-------DRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYG 433
             .::..:|.:.|..:.::.||.       |:..:...|  :| :::|:...|...:..:...|.|
 Worm   396 -TEENHEDFEALREEAKKMYLKKLSDDEDDKEVAARGY--IQ-LYSDLFVNNGTYNYAEKMTKLG 456

  Fly   434 -KSPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTA-----AYRTGIRPDEEVISK 492
             |..:|||.|.||...|:   ||.|......| |..:...||..:     .|....|...::::|
 Worm   457 NKVFMYSFDYCNPRSFGI---LSLRAPFRAAT-HCTELAYIFGVSIVFNYRYNESDRAMLDLMTK 517

  Fly   493 KFI---------GMLEDFALNDKGTLTFGECNFQNNVNSKE--YQVLRISRNACK 536
            .:.         |..||..:.|          |:....|||  ...|.|:...|:
 Worm   518 MWTNFAKYGNPNGQYEDSTVFD----------FKWEPTSKEEPTNFLAINEKKCE 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	153/575 (27%)
		Aes	<107..>240	CDD:223730	52/140 (37%)
cest-26	NP_001368609.1	COesterase	40..575	CDD:395084	153/575 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910