Protein Alignment Est-P and cest-2.2

DIOPT Version :9

• Sequence 1: NP_788501.1
• Gene: Est-P / 39393
• FlyBaseID: FBgn0000594
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_001256567.1
• Gene: cest-2.2 / 179917
• WormBaseID: WBGene00013874
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 581
• Identity: 134/581 - (23%)
• Similarity: 215/581 - (37%)
• Gaps: 130/581 - (22%)

  Fly    12 LLWIAALESEADPLIVEITNGKIRGKDNGLYYS---------YESIPNAEHPTGALRFEAPQPYS 67
            :||.......:..:.:....|.|.|:.....||         :..:|..|.|.|.|||..|:| .
 Worm     7 ILWAILQNVRSTKVKLSSRTGTIEGRTLTASYSPLGNQTGIVFFGVPYVEPPVGNLRFRKPRP-P 70

  Fly    68 HHWTDVFNATQSPVECMQWNQFINENNKLMG--DEDCLTVSI----YKPKKPNRSSFPVVVLLHG 126
            ..|..|..|.:....||. :|.....|.:.|  .||||..::    |..:..|.|   |::.:||
 Worm    71 KPWDGVLEAKEYKAACMS-DQKKTYKNGVGGPVSEDCLYANVFTNQYCLEHKNCS---VMLTIHG 131

  Fly   127 GAFMFGSGSIYGHDSIMR----EG-TLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWI 186
            |.|:..|.|.|..:.|:.    :| .::||..::.||..|.......:...|:||.|....::|.
 Worm   132 GRFVIESASAYDPEIIINNFVGQGRNIVVVTFNYRLGLFGLGMLNGDNQDTNFGLYDILEVVRWT 196

  Fly   187 KKNIAHFGGMPDNIVLIGHSAGG------ASAHLQ--LLHED-FKHLAKGAISVSGNALDPWVIQ 242
            :|.|.:|||..|.|.:.|||||.      :::.|.  |:|:. ....:...:|...|..:..|:
 Worm   197 RKEIKNFGGDKDRITMQGHSAGAVFTAAFSTSPLSKGLIHQQIIMSASMSNLSKKSNVKELTVV- 260

  Fly   243 QGGRRRAFELGRIVGC---GH-----TNVSAE-LKDCLKSKPASDIVSAVRSFLVFSYVPFSAFG 298
                      .|||||   .|     :||..| ...||:||.|..|:.|
 Worm   261 ----------ARIVGCLPDEHGFPKLSNVEVEKAYTCLRSKSAQQILDA---------------- 299

  Fly   299 PVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDR 363
                     ..::..:....|..|....: :.|.|  .|..|....:...|.:.|.:..:|::.|
 Worm   300 ---------QLYMLRNTTYYIGQGHIDGI-YQVDY--PDNLYATNSIYPINTMIGTTTAELMDSR 352

  Fly   364 WFDWAPYLLFYRDAKKTIKD-------MDDLSFDLRQQYLADRRFSVES---YWN---VQRMFTD 415
                  |::   |.|.|.|.       .:.:.::|   |.....||.:.   |.|   .:.:..|
 Worm   353 ------YIV---DPKNTGKKEILLQNLCEHIGYEL---YKEPEEFSQKCRNFYKNGEDAKSLGDD 405

  Fly   416 VLFKNSVPSAIDLHRKYGKSP-VYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAY 479
            :.|........::|.....:. ||||.|....::      ..:.|......||:||...|.|  .
 Worm   406 MEFYYGAIQLANVHSSKDTNVFVYSFDYKEAGNA------YKKYDKSLSPKHGEDFAYAFGT--N 462

  Fly   480 RTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECN-------FQNNVNSKEYQVLRISRN 533
            |......:.||...:.||..||       :.||:.:       .|.....:||.::...:|
 Worm   463 RGNFSTKDYVIEYIYSGMFADF-------VNFGDPSPLEDQEWAQYTPEKREYFLIDFDKN 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	132/567 (23%)
		Aes	<107..>240	CDD:223730	40/150 (27%)
cest-2.2	NP_001256567.1	Abhydrolase	25..534	CDD:389770	132/563 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156995
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940