Protein Alignment Est-P and cest-1.2

DIOPT Version :9

• Sequence 1: NP_788501.1
• Gene: Est-P / 39393
• FlyBaseID: FBgn0000594
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_506504.2
• Gene: cest-1.2 / 179914
• WormBaseID: WBGene00011364
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 601
• Identity: 150/601 - (24%)
• Similarity: 244/601 - (40%)
• Gaps: 132/601 - (21%)

  Fly     3 IFKRLLCLTLLWIAALESEADPLIVEITNGKIRGKDNGLYYS---------YESIPNAEHPTGAL 58
            |||   .:.|||.:|  ..|....|:::.|.|.||.....||         :..||..|.|.|.|
 Worm     2 IFK---FVVLLWFSA--QFAISTKVQLSTGIIEGKQLNSTYSPFGNQSAIAFLGIPYVEPPIGDL 61

  Fly    59 RFEAPQPYSHHWTDVFNATQSPVECMQWNQFINENNKLMG--DEDCLTVSI----YKPKKPNRSS 117
            ||..|:| ...|:.|....:....||..:....:|..:.|  .||||.:::    |..:..|.|
 Worm    62 RFRKPRP-QKTWSGVLETKKFKPACMSNSTKTYKNGGIGGPISEDCLYLNVLTNQYCLENKNCS- 124

  Fly   118 FPVVVLLHGGAFMFGSGSIYGHDSIM-----REGTLLVVKISFGLGPLGFASTGDRHLPG----- 172
              ||:::|||.::|.|.:.:.|:.::     ::..::||.|::.||..||.     ||.|
 Worm   125 --VVIIVHGGGYLFESAATFNHEILVNNFVGQDRNIVVVTINYRLGIFGFG-----HLNGFEGDK 182

  Fly   173 NYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAG-GASAHLQLLHEDFKHLAKGAISVSGNAL 236
            |.|:.|...|::|:::.|..|||..|.|.|.||||| |..|...:     ..|.||.|...
 Worm   183 NVGIFDTLEAVKWVRREIKQFGGNKDRITLAGHSAGAGVVAAFTI-----SPLTKGLIHQQ---- 238

  Fly   237 DPWVIQQG-----GRRRAFE----LGRIVGCGHT----------NVSAELKDCLKSKPASDIVSA 282
               ::..|     .::..|:    :...||| |:          :...::..||:.|||.:::.|
 Worm   239 ---IVMSGPMTNMSKKSNFKGMTAMAERVGC-HSKKYGFNKLPEHEVEQVYSCLRKKPAQELLDA 299

  Fly   283 VRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLE 347
            ....|..|...|.|  |.|:     ..|:|:.|                     |..|:...:..
 Worm   300 QLWLLQNSTFYFGA--PPVD-----GEFITDYP---------------------DNLYSEKSIFS 336

  Fly   348 RNKLTGESWIDLLNDRWFDWAPYLLFYRDAKKT-IKDM-DDLSFDLRQQYLADRRFSVE-SYWNV 409
            .|.|.|.:..:|.:..:...:.|..|  :.|:| :|:: |.:..::   |.....||.: ..|.:
 Worm   337 INTLLGTTTRELQDTGYISNSNYSKF--ETKETFLKNLCDQIGIEI---YKESEDFSSKCQKWYI 396

  Fly   410 -----QRMFTDVLFKNSVPSAIDLHRKYGKSP-VYSFVYDNPTDSGVGQLLSNRTDV---HFGTV 465
                 :.:..|:.|.....:..|.|.:.||.. :||:.|     ||.|........|   |
 Worm   397 NGSDSKSLSDDMEFYTQAINLADAHARKGKKVYMYSYAY-----SGAGPAFKKYMKVKSPH---- 452

  Fly   466 HGDDFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECNFQNNVNSKEYQVLRI 530
            |.:|  ||:....:|....|.:.||...:.||..||...:..:.:..:...|....:|||.::..
 Worm   453 HSED--LIYTFGTHRGVFAPKDYVIEYIYSGMFADFINFEDPSPSTDQPWLQYTKENKEYFLVDF 515

  Fly   531 SRN----ACKNEEYAR 542
            .:|    ..|...||:
 Worm   516 DQNLTMPGMKKNYYAK 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	139/571 (24%)
		Aes	<107..>240	CDD:223730	44/147 (30%)
cest-1.2	NP_506504.2	COesterase	21..536	CDD:278561	142/577 (25%)
		Aes	<125..>250	CDD:223730	42/141 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156999
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840