DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and cest-33

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_504621.1	Gene:	cest-33 / 179020	WormBaseID:	WBGene00017431	Length:	554	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	139/548 - (25%)
Similarity:	225/548 - (41%)	Gaps:	81/548 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IAALESEADPLIVEITNGKIRGKDNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQS 79
            :.||::...|:     .|.|...|:.:...|..||.|:.|.|.|||:.|.... .||::.:..:.
Worm    14 VEALKASCGPV-----RGNIYKHDDVIVDGYLGIPYAKPPVGELRFKKPVTVD-VWTEIKDCYKY 72

  Fly    80 PVECMQ---WNQFINENNKLMGDEDCLTVSIYKPKKPN---RSSFPVVVLLHGGAFMFGSGSIYG 138
            ...|:|   :.|..........:..|||::::.|:..:   ::..||:|.:|||.:...:.|.:.
Worm    73 GPACVQTGGFEQIAGPRTPTPEEAGCLTLNVFTPRNASSEFKNGRPVMVYIHGGGYELCASSDFC 137

  Fly   139 HDSIMREGTL-----LVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPD 198
            ..|:  .|||     :||.|::.||..||.:|||...|||:||.||.|||:|::|:|:.|||.|:
Worm   138 AYSL--SGTLPLKDVVVVSINYRLGVFGFLTTGDNVCPGNFGLWDQTLALKWVQKHISSFGGDPN 200

  Fly   199 NIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQG-GRRRAF-ELGRIVGCGHT 261
            .:.:.|.||||||..|..|....:.|.:..|.:||.|...:.|:.. .:.:.| |.....|....
Worm   201 CVTVFGQSAGGASTDLLSLSPHSRDLFQRFIPISGTAHCDFAIRASENQAKIFREFAEFHGFSGR 265

  Fly   262 NVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAP---DAFLTEDPRAVIKSGK 323
            :.||..|...:..|  :.:|.|:.:.. |...|..|.|.::....|   |....|.|:..:.:|
Worm   266 DSSALFKWYQEQSP--ETLSNVKGYKK-SISGFLTFIPNLDGDFFPKPLDELRKEAPKKQMMTG- 326

  Fly   324 FAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYRDAKKTIKDMDDLS 388
                      .||   |....|...|.....:.:.|      ...|..::.:|   .:.:.|::.
Worm   327 ----------VTE---YEGLMLASMNPAFSPADVGL------TLMPQGIYGKD---VVSNPDEIQ 369

  Fly   389 FDLRQQYL--ADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSP-VYSFVYDNPTDSGV 450
            ....::|:  .|:...:.....:.....|..|...|..|.....|:|... .|:|.|.||...|:
Worm   370 KIFYEKYVEGVDKSDELAMRKKLCEALGDEFFNVGVIQAAKNAAKHGNEVYFYTFEYVNPDSFGM 434

  Fly   451 GQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIR--PDEEVISKKFIGMLEDFALNDKGTLTFGE 513
            .                 |..:.|..|.:.|.:|  ..|.|.| ||....||..:.:..|..|..
Worm   435 W-----------------DGMMPFKAAVHCTELRYLLGEGVYS-KFEPTEEDRKVMETTTTLFSN 481

  Fly   514 CNFQNNVNSK--------EYQVLRISRN 533
            .....|.|.|        :|.:.|..|:
Worm   482 FAKYGNPNGKGATAEIWEKYSLNRPERH 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	136/537 (25%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	53/140 (38%)
cest-33	NP_504621.1	Esterase_lipase	16..521	CDD:238191	139/546 (25%)
cest-33	NP_504621.1	Aes	<103..>224	CDD:223730	48/122 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810