DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and cest-24

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_504613.1	Gene:	cest-24 / 179017	WormBaseID:	WBGene00020891	Length:	658	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	136/557 - (24%)
Similarity:	218/557 - (39%)	Gaps:	126/557 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EADPLIVEITNGKIRG-----KDNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQSP 80
            :::..||.:..|.:.|     ....|...:..||.||.|.|.|||:.||| ...|..:....:.|
Worm    92 KSENAIVRVQQGLLEGFRVKTAKGDLCDVFHGIPYAEPPVGELRFQKPQP-PKAWEGIRKCNKYP 155

  Fly    81 VEC----MQWNQFINENNKLMGDEDCLTVSIYKPKKPNRSSFPVVVLLHGGAFMFGSGSIYGHDS 141
            ...    |.|::.:...|:   .||||.::::.||......:||:..:|||.::..|...|...:
Worm   156 NRSIHKEMPWDKALPSANQ---SEDCLYLNVFAPKIREDKKYPVLFYIHGGGYVMDSAERYTAKN 217

  Fly   142 IMR---EGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLI 203
            |.:   ...::||...:.||.|||.||||...||||||.|...|::|:..||:.|||.|:||.|.
Worm   218 ICKLLVSREIIVVTFHYRLGFLGFLSTGDDVCPGNYGLFDMLEAMRWVHANISSFGGDPENITLS 282

  Fly   204 GHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWV------IQQGGRRRAFELGRIVGCGHTN 262
            |.|||.|:|.|.......|.|.|..|.:.||:...|.      |::..::.|..||......:.|
Worm   283 GQSAGAAAADLLSFSPLTKGLFKRKIVMGGNSYCHWATTSNHDIREYCKKWAKRLGWKPQLNYAN 347

  Fly   263 VSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFG------------------PVVEPSDAPDA 309
                     |.:.:.||      |..|:.:|.|..|                  ||::....|..
Worm   348 ---------KREESVDI------FNFFNGLPTSKLGMTMFFSNTIFKECQLPLAPVIDGEILPHD 397

  Fly   310 F-----LTEDPRAVIKSGKFAQVPW---AVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFD 366
            .     ..|...:::..|::..:.:   .:...||....:|..:|.|......|.|:.:.::.:.
Worm   398 LKVLRETQEHVPSLVGGGEYEALLFCAIGLLRGTEKEINSAIDVLSRKNRLSRSKIEAMTEKVYG 462

  Fly   367 WAPYLLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRK 431
            .:|                    .||....|.:.|.|:       :.:|: |.|
Worm   463 DSP--------------------ALRADSKARKMFFVQ-------LISDI-FAN----------- 488

  Fly   432 YGK-----------SPVYSFVYDNPTDSGVGQLLSNRTDVHF-GTVHGDDFFLIF--NTAAYRTG 482
            ||.           ...|.:.:|:.:....|.|   :..|.| |..|..:...:|  |..:...|
Worm   489 YGNYRFMRDCQQRGVECYGYSFDHQSKQMWGWL---QHVVPFTGGTHTSELSYLFDCNYMSAPLG 550

  Fly   483 IRPDEEVISKKFIGMLEDFALNDKGTLTFGECNFQNN 519
            :...::|:|    ||..|:..|   .:.||..|..|:
Worm   551 MNKTDKVVS----GMTADYFTN---FVKFGTPNGPNS 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	136/552 (25%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	52/135 (39%)
cest-24	NP_504613.1	COesterase	97..608	CDD:278561	136/552 (25%)
cest-24	NP_504613.1	Aes	<183..>285	CDD:223730	40/101 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010