DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and cest-10

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_501133.3	Gene:	cest-10 / 177493	WormBaseID:	WBGene00016595	Length:	579	Species:	Caenorhabditis elegans

Alignment Length:	589	Identity:	133/589 - (22%)
Similarity:	218/589 - (37%)	Gaps:	140/589 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LTLLWIAALESEADPLIVEITNGKIRGKDNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVF 74
            :.:|::.:.....|.:|||.:.||:.|...|.::.::.||.|:.|.|.|||:.||| :..|..|.
Worm     7 IQILFLFSFSCFVDSVIVETSLGKLNGDQIGNFHLFKKIPFAKPPLGKLRFQKPQP-AETWNGVR 70

  Fly    75 NATQSPVECMQWNQFINENNKLMGDEDCLTVSIYKPKKPNRS-SFPVVVLLHGGAFMFGSGSIYG 138
            ||......||. |....:..:...|||||.::|:..:...:| :..||:.||||...:.|..::.
Worm    71 NAKDYGPACMS-NSSTTKTVQKWVDEDCLHLNIFTSETCLKSKNCAVVIYLHGGNLHYDSAVMFN 134

  Fly   139 -----HDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPD 198
                 |....:|...::..:..|:.. .|........|.|..|.|...|:::.|.:|.:|||...
Worm   135 DTFLLHTYASQEIVFVIPAVRLGIFS-HFVVEDQSIAPNNLALFDMLQAMEFAKSDIHNFGGNNK 198

  Fly   199 NIVLIGHSAGGASAHL----QLLHEDFKHLAKGAISVSG-NALDPWVIQQGGRRRAFELGRIVGC 258
            ...|:|||.||..|.:    ..::.|.. |.:..||:|. ...|...:|.   .|.:.......|
Worm   199 RTTLLGHSYGGTVASMLSFSTKVNTDLS-LFQQYISMSSPTNFDTLELQV---ERTYRFAEHANC 259

  Fly   259 GHTN--------VSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAF---GPVVEPSDAPDAFLT 312
            ...|        ....::||||.|.||:::...||.....|..:...   ||:.:      ..|.
Worm   260 LPKNSKFMRKNQKEVYMRDCLKKKSASELLRIQRSLEEAGYPVYGGSVMRGPIFQ------EVLE 318

  Fly   313 EDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTG-ESWIDLLNDRWFDWAPYLLFYRD 376
            .|         |...|..:|                 .||| ..:..|:.|.          ||:
Worm   319 RD---------FMDSPNNIT-----------------SLTGCTKYESLVYDH----------YRN 347

  Fly   377 AKKTIKDMDDLSF----DLRQQYLADRRFSVESYWNVQ----------RMFTDVLFKNSVPSAID 427
            ..|.      |.|    ::.::|.:|.:.....:.||:          |...:.:.|.::|:
Worm   348 MGKA------LGFENYEEVNEKYRSDSKEGKIEFDNVKNATQIMLIQIRTRVNKILKKNIPA--- 403

  Fly   428 LHRKYGKSPVYSFVYD---NPTDS-----GVGQLLSNRTDVHFGTVHGDDFFLIF---------- 474
            .|        |.:.|.   |.||.     ||...:.:..::..|..: ...||.|
Worm   404 YH--------YEYAYPKHANHTDDLFFIMGVHPFIQDENEIKLGNFY-RSMFLNFIKTGNPGNGC 459

  Fly   475 -----NTAAY-------RTGIRPDEEVISKKFIGMLEDFALNDKGTLTFG-ECNFQNNVNSKEYQ 526
                 |.:.|       .||.||   |:...|...:.|:.  .|..:.|. |.:...|:.|:...
Worm   460 DGANLNGSTYFEVNWNETTGERP---VMKNNFEQKILDYW--TKNMIEFDREVSLLRNIKSRRQP 519

  Fly   527 VLRI 530
            ..|:
Worm   520 ASRV 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	131/573 (23%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	36/143 (25%)
cest-10	NP_501133.3	Abhydrolase	23..503	CDD:389770	126/551 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740