DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and cest-4

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_501043.1	Gene:	cest-4 / 177445	WormBaseID:	WBGene00015930	Length:	592	Species:	Caenorhabditis elegans

Alignment Length:	592	Identity:	137/592 - (23%)
Similarity:	237/592 - (40%)	Gaps:	118/592 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLCLTLLWIAALESEADPLIVEITNGKIRGKDNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWT 71
            ||.|:...:.::...|   ||..:.|:|.|...|.::.::.||.|:.|.|.|||:.|:| ...||
Worm    12 LLFLSFFLLFSITKSA---IVSTSLGQIDGDQIGSFHLFKHIPLAKPPIGKLRFQKPEP-PEKWT 72

  Fly    72 DVFNATQSPVECMQWNQFINENNKLMGDEDCLTVSIYKPKKPNRS-SFPVVVLLHGGAFMFGSGS 135
            .|.||......|:. |..::.:.:...|||||.::|:...|..:| ...||...|||..|:.|..
Worm    73 GVRNAKAYGPACIS-NSSVSTSPQKWIDEDCLHINIFTSDKCLKSKDCAVVTYFHGGGLMYDSAV 136

  Fly   136 IYGHDSIMREGTL----LVVKI-SFGLGPLGFASTGDRHL-PGNYGLKDQRLALQWIKKNIAHFG 194
            ::....::  ||.    :::.| :|.||........|:.: |.|..|.|..|.::::|..|.:||
Worm   137 MFNDTYLL--GTFVNQDVIIAIPAFRLGIFSHFVVEDQSIAPTNLALYDILLGVEFVKNEIHNFG 199

  Fly   195 GMPDNIVLIGHSAGGASAHLQLLHEDFKH---LAKGAISV-SGNALDPWVIQ-QGGRRRAFELG- 253
            |......::|||.||:..::........|   |.:.:|.: ||:..:...|| |...|.|...|
Worm   200 GNNQKNTIMGHSYGGSIVNILTFSSKINHDLSLFQQSICMSSGHDFETLEIQIQKTNRFAKHAGC 264

  Fly   254 ---RIVGCGHTNVSAEL--KDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTE 313
               .|:....|...::|  ..||::|.|.:::...|   :.....:..:|.:|:    .:..:.|
Worm   265 TVPSIIEKKMTTRQSDLYRMKCLQNKDALELLRVQR---LLEDEGYPTYGYLVQ----REPLIQE 322

  Fly   314 DP-RAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYRDA 377
            .| :..:||.|  ::|.....|..:..::.|.     |..|:: :...|..    ..|:.|.
Worm   323 IPYQEFMKSPK--KIPMLTGCTRYEMDHSPAP-----KPIGQA-LGFENPE----EVYMKFR--- 372

  Fly   378 KKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPVYSFVY 442
                ||.||..::........:...|:    |:....::|.||              .|.|.:.|
Worm   373 ----KDWDDEVYEFGNHSDETQAIMVQ----VRVRVNNLLSKN--------------VPAYLYEY 415

  Fly   443 DNP-----TDS-----GVGQLLSNRTDVHFGTVHGDDFFLIF----------------NTAAY-- 479
            ..|     ||.     ||.:...:..::..|.|: :..|:.|                |.:.|
Worm   416 TYPKHARHTDDLFYLMGVHRFEKDENEIELGKVY-ETIFMNFAKFGDPKEGFELANAENESYYEV 479

  Fly   480 ----RTGIRP------DEEVISKKFIGMLEDFALNDKGTLTFGECNFQNNVNSKEYQVLRISRNA 534
                .||.||      :|::|:.    .|:|....||..     ...:|...|....|:|....:
Worm   480 YWDGETGERPQMKTKFEEKIINY----WLKDMVEYDKHI-----TELKNQKISIRKPVVRFYEES 535

  Fly   535 CKNEEYA 541
            .|..:|:
Worm   536 SKYHQYS 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	131/567 (23%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	37/143 (26%)
cest-4	NP_501043.1	Abhydrolase	28..503	CDD:389770	123/527 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810