DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and cest-27

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_871861.2	Gene:	cest-27 / 171610	WormBaseID:	WBGene00018958	Length:	561	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	144/545 - (26%)
Similarity:	235/545 - (43%)	Gaps:	103/545 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 EITNGKIRG-----KDNGLYYSYESIPNAEHPTGALRFEAPQPYSHH-WTDVFNATQSPVECMQW 86
            :.|.|.|:|     :|..:...:..||.||.|.|||||:  :|.:|. ||:       |::|:::
Worm    29 DATCGPIKGVGYEQEDGSVVEGFLGIPYAEPPIGALRFK--KPVAHRKWTE-------PLDCVRF 84

  Fly    87 NQFINENNKLMG---------DEDCLTVSIYKPKKPNR---SSFPVVVLLHGGAFMFGSGSIYGH 139
            .....:|::|:|         :|.||:::::.||..:.   ..|||:|.:|||.|...|.|.||.
Worm    85 GPRSPQNDELLGQFVNTVGKSEEHCLSLNVFTPKWESNEWPDGFPVMVFIHGGGFAVHSSSNYGC 149

  Fly   140 DSIMRE---GTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIV 201
            .||.|.   ..::||.|::.||.|||.:|||....||.||.||..||:|:::||..|.|.|||:.
Worm   150 ASIARNLCTKDVVVVTINYRLGVLGFFTTGDEVCRGNLGLWDQTAALEWVQENIQSFRGDPDNVT 214

  Fly   202 LIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVI----QQGGRRRAFELGRIVGC-GHT 261
            :.|.||||||..|..|....:.|...||.::||....:.:    ||....|  |..|.:|. |..
Worm   215 IFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQQAQLSR--EFARYLGWEGDD 277

  Fly   262 NVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPV-VEPSDAPDAFLTEDPRAVIKSGKFA 325
            |.|.:|...:..:|...|...:.....|.:   |..|.: ..|:...|.|    |:.:.:..|.|
Worm   278 NDSEDLLQFIDQQPLYKIEMGINPKRGFKH---SQAGSLYFVPNFDGDFF----PKPLNQLRKEA 335

  Fly   326 QVPWAVTYTTEDGG--YNAAQLLERN-----KLTG------------ESWIDLLNDRWFDWAPYL 371
            .....:|.||:..|  :.|...|.:|     |..|            :..:.::.|.:|..
Worm   336 PKMQIMTGTTKYEGLFFIALGALSKNPEGIKKFMGRIFKECDYGERADDVLQMVYDFYFKG---- 396

  Fly   372 LFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSP 436
            :..:|.:|.:..:        .:::.|...:..:| .:..:.||:           .|..|
Worm   397 VHPKDHEKNMHQI--------VKFIGDYSINYGTY-RLANIMTDL-----------QHDVY---- 437

  Fly   437 VYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDF 501
            .|.|.|.|....||.:.|.    ...|:.|..:...:...... :..||::.  .||.:.::..:
Worm   438 FYQFDYHNSAGFGVFRWLL----PFLGSTHCTEMRYVLGKGII-SKFRPNDN--DKKMLHVMTTY 495

  Fly   502 ALNDKGTLTFGECNFQNNVNSKEYQ 526
            ..|   ...:|..|.:|. .:.|:|
Worm   496 FTN---FAKYGNPNGENQ-ETGEWQ 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	144/545 (26%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	58/138 (42%)
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	144/545 (26%)
cest-27	NP_871861.2	Aes	<114..>283	CDD:223730	67/170 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157213
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840