DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-P and Ces3b

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_653094.2	Gene:	Ces3b / 13909	MGIID:	3644960	Length:	571	Species:	Mus musculus

Alignment Length:	509	Identity:	137/509 - (26%)
Similarity:	207/509 - (40%)	Gaps:	124/509 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SIFKRLLCLTLLWIA------ALESEAD-PLIVEITNGKIRGKDNG------LYYSYESIPNAEH 53
            |:...:.||.|.::.      .::.|.| ||      |::||:..|      :...:..||.|:.
Mouse    13 SVLVWVTCLLLAFVTTVTGPKVIQPEVDTPL------GRVRGRQVGVKDTDRMVNVFLGIPFAQA 71

  Fly    54 PTGALRFEAPQPYSHHWTDVFNATQSPVECMQ------WNQF-INENNKLMG-DEDCLTVSIYKP 110
            |.|.|||.||.| ...|..|.:|:.:|..|:|      .::| :||..|:.. .|||||::||.|
Mouse    72 PVGPLRFSAPLP-PQPWEGVRDASINPPMCLQDVEKMINSRFGLNEKIKIFPISEDCLTLNIYSP 135

  Fly   111 KKPNR-SSFPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNY 174
            .:... ...||:|.:|||:.:.||.:.....::...|.::||.:.:.||..||.||||:|:|||.
Mouse   136 TEITAGDKRPVMVWIHGGSLLVGSSTSQDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHMPGNR 200

  Fly   175 GLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSG------ 233
            |..|...||:|::.|||.|||.|:.:.:.|:||||.......|......|...|||.||
Mouse   201 GFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIM 265

  Fly   234 -NALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAF 297
             ..:.||       ..|......|.||..: .|||..||..|...|::.  :..:..||:
Mouse   266 MEDMKPW-------PEAQNFANSVACGSAS-PAELVQCLLQKEGKDLIK--QKNVNISYI----- 315

  Fly   298 GPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLND 362
                    ..|:|..:.|..::...:|..||:.:..|..:.|                |:.|
Mouse   316 --------VNDSFFPQRPEKLLADQQFPTVPYLLGVTNHEFG----------------WLLL--- 353

  Fly   363 RWFDWAPYLLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAID 427
                            |::..:|.|           ...|.|....:.|.|..::   .||..|
Mouse   354 ----------------KSLNILDKL-----------EHLSREDLLEISRPFLAIM---EVPPEI- 387

  Fly   428 LHRKYGKSPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLI--FNTAAY 479
                   .|.   |.|...|:|..|   :.|...|..:.||..|:|  .|.:.|
Mouse   388 -------MPT---VIDEYLDNGSDQ---SATRYAFQELLGDISFIIPTLNFSKY 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	129/478 (27%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	51/140 (36%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	133/486 (27%)
		Aes	75..>245	CDD:223730	65/170 (38%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832474
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840