DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Ces1e

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_598421.1	Gene:	Ces1e / 13897	MGIID:	95432	Length:	562	Species:	Mus musculus

Alignment Length:	579	Identity:	164/579 - (28%)
Similarity:	245/579 - (42%)	Gaps:	121/579 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LCLTLLWIAALES-------EADPLIVEITNGKIRGKDNGLYYSYE----------SIPNAEHPT 55
            :||:.|.:.:|.:       .:.|.:|:...||:.||    |.|.|          .:|.|:.|.
Mouse     1 MCLSALILVSLAAFTAGAGHPSSPPMVDTVQGKVLGK----YISLEGFTQPVAVFLGVPFAKPPL 61

  Fly    56 GALRFEAPQPYSHHWTDVFNATQSPVECMQ---WNQFINE---NNK----LMGDEDCLTVSIYKP 110
            |:|||..||| :..|:.|.|||..|..|.|   ..|.:|:   |.|    |...||||.::||.|
Mouse    62 GSLRFAPPQP-AEPWSSVKNATSYPPMCFQDPVTGQIVNDLLTNRKEKIPLQFSEDCLYLNIYTP 125

  Fly   111 KKPNRSS-FPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNY 174
            ....:|. .||:|.:|||..:.|..|.|....:.....::||.|.:.||..||.||||.|..||:
Mouse   126 ADLTKSDRLPVMVWIHGGGLVLGGASTYDGLVLSTHENVVVVVIQYRLGIWGFFSTGDEHSRGNW 190

  Fly   175 GLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPW 239
            |..||..||.|::.|||.|||.|.::.:.|.||||.|..:.:|....|:|.:.|||.||.||...
Mouse   191 GHLDQVAALHWVQDNIAKFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFQRAISESGVALTAG 255

  Fly   240 VIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFG------ 298
            ::::..|..|.::..|.||.:| .||.:..||:.|...:::.......:|.   ....|
Mouse   256 LVKKNTRPLAEKIAVISGCKNT-TSAAMVHCLRQKTEEELLGTTLKLNLFK---LDLHGDSRQSH 316

  Fly   299 PVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDR 363
            |.| |:......|.:.|..::....|..||:.|.                           :|.:
Mouse   317 PFV-PTVLDGVLLPKMPEEILAEKNFNTVPYIVG---------------------------INKQ 353

  Fly   364 WFDW-APYLLFYRDAKKTIKDMDDL------SFDLR----------QQYLADRRFSVESYWNVQR 411
            .|.| .|.::.|..:...:..|..:      ||.|.          ::||.|:.::..:...:..
Mouse   354 EFGWILPTMMNYPPSDVKLDQMTAMSLLKKSSFLLNLPEDAIAVAIEKYLRDKDYTGRNKDQLLE 418

  Fly   412 MFTDVLFKNSVPSAIDL--HRKYGKSPVY--------SFVYDNPTDSGVGQLLSNRTDVHFGTVH 466
            :..||:|  .|||.|..  ||..| :|.|        ||..:...|:.||.             |
Mouse   419 LIGDVVF--GVPSVIVSRGHRDAG-APTYMYEFQYSPSFSSEMKPDTVVGD-------------H 467

  Fly   467 GDDFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECNFQNNVNSKEY 525
            ||:.:.:|.....|.|...:|..:||..:....:||.|       |..|.|...:..||
Mouse   468 GDEIYSVFGAPILRGGTSEEEINLSKMMMKFWANFARN-------GNPNGQGLPHWPEY 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	159/554 (29%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	56/133 (42%)
Ces1e	NP_598421.1	COesterase	25..546	CDD:278561	159/555 (29%)
		Aes	44..>242	CDD:223730	76/198 (38%)
		Prevents secretion from ER. /evidence=ECO:0000255	559..562
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832795
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840