DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Ces1c

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus

Alignment Length:	509	Identity:	146/509 - (28%)
Similarity:	232/509 - (45%)	Gaps:	66/509 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PLIVEITNGKIRGKDNGLYYSYE----------SIPNAEHPTGALRFEAPQPYSHHWTDVFNATQ 78
            |.:|:.|.||:.||    |.|.|          .:|.|:.|.|:|||..||| :..|:.|.|||.
Mouse    23 PPVVDTTQGKVLGK----YISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQP-AEPWSFVKNATS 82

  Fly    79 SPVECMQ---WNQFIN-------ENNKLMGDEDCLTVSIYKPKKPNRSS-FPVVVLLHGGAFMFG 132
            .|..|.|   |.:.::       |...|...||||.::||.|....:|| .||:|.:|||..:.|
Mouse    83 YPPMCSQDAGWAKILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIG 147

  Fly   133 SGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMP 197
            ..|.|...::.....::||.|.:.||..|..||||.|.|||:...||..||:|::.|||:|||.|
Mouse   148 GASPYNGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLAALRWVQDNIANFGGNP 212

  Fly   198 DNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVG----C 258
            |::.:.|.|:||.|..:.:|....|.|...|||.||..::..|    |::....:..|:.    |
Mouse   213 DSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVINTNV----GKKNIQAVNEIIATLSQC 273

  Fly   259 GHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGK 323
            ..|: ||.:..||:.|..|:::......:.::....:....||.|. ||:..|.|      ||
Mouse   274 NDTS-SAAMVQCLRQKTESELLEISGKLVQYNISLSTMIDGVVLPK-APEEILAE------KS-- 328

  Fly   324 FAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYRDAKKTIKDMDDLS 388
            |..||:.|.:..::.|:....:|:          :||.:...:.....|..|.....:...:.:.
Mouse   329 FNTVPYIVGFNKQEFGWIIPMMLQ----------NLLPEGKMNEETASLLLRRFHSELNISESMI 383

  Fly   389 FDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPVYSFVYD---NPTDSGV 450
            ..:.:|||.......:....:..||.|:.|  .:| |:.|.|....:.|.:::|:   .|:
Mouse   384 PAVIEQYLRGVDDPAKKSELILDMFGDIFF--GIP-AVLLSRSLRDAGVSTYMYEFRYRPS---- 441

  Fly   451 GQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALN 504
              .:|::........|||:.|.:|.....:.|...:|..:||..:....:||.|
Mouse   442 --FVSDKRPQTVEGDHGDEIFFVFGAPLLKEGASEEETNLSKMVMKFWANFARN 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	145/507 (29%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	54/133 (41%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	145/507 (29%)
		Aes	<121..>234	CDD:223730	47/112 (42%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832537
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840