DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Cel

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_034015.1	Gene:	Cel / 12613	MGIID:	88374	Length:	599	Species:	Mus musculus

Alignment Length:	525	Identity:	156/525 - (29%)
Similarity:	229/525 - (43%)	Gaps:	123/525 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 YESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQSPVECMQWNQFINENNKLMGDEDCLTVSIYK 109
            ::.||.|...|    .|.||.:. .|.....||.....|:|  ..|.::| ..|.||||.::|:.
Mouse    51 FKGIPFATAKT----LENPQRHP-GWQGTLKATNFKKRCLQ--ATITQDN-TYGQEDCLYLNIWV 107

  Fly   110 P--KKPNRSSFPVVVLLHGGAFMFGSGS--------IYGHDSIMREGTLLVVKISFGLGPLGFAS 164
            |  :|....:.||:|.::||||:.|||.        :|..:.|...|.::||..::.:|||||.|
Mouse   108 PQGRKQVSHNLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFLS 172

  Fly   165 TGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAI 229
            |||.:||||:||:||.:|:.|:|:|||.|||.||||.:.|.|||.||..||.|....|.|.:.||
Mouse   173 TGDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRAI 237

  Fly   230 SVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVR------SFLV 288
            |.||.||.||.||:.....|..:.:.||| .|..:.::..|||......:..|.:      .:.|
Mouse   238 SQSGMALSPWAIQKNPLFWAKTIAKKVGC-PTEDTGKMAACLKITDPRALTLAYKLPVKKQEYPV 301

  Fly   289 FSYVPFSAFGPVVEPSDAPD------------------------AFLTEDPRAVIKSGKFAQVPW 329
            ..|:   ||.||::....||                        .|.|.|..||.|:.:
Mouse   302 VHYL---AFIPVIDGDFIPDDPINLYNNTADIDYIAGINNMDGHLFATIDVPAVDKTKQ------ 357

  Fly   330 AVTYTTED-----GGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYRDAKKTIKDMDDLSF 389
              |.|.||     .|:..|:.|:..:.|    .|:..:.|.....    ..:.|||:     ::|
Mouse   358 --TVTEEDFYRLVSGHTVAKGLKGAQAT----FDIYTESWAQDPS----QENMKKTV-----VAF 407

  Fly   390 DLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKS-PVYSFVYDNPTDSGVGQL 453
            :                       |||||......|:..|:.:.|| ..||:::.:|
Mouse   408 E-----------------------TDVLFLIPTEIALAQHKAHAKSAKTYSYLFSHP-------- 441

  Fly   454 LSNRTDVH---FGTVHGDDFFLIFNTA-AYRTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGEC 514
              :|..::   .|..|.||...:|... |...|.||.:..:||..|....:||.:       |:.
Mouse   442 --SRMPIYPKWMGADHADDLQYVFGKPFATPLGYRPQDRAVSKAMIAYWTNFARS-------GDP 497

  Fly   515 NFQNN 519
            |..|:
Mouse   498 NMGNS 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	156/525 (30%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	67/142 (47%)
Cel	NP_034015.1	COesterase	26..542	CDD:278561	156/525 (30%)
		Aes	<117..>247	CDD:223730	63/129 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..599
		4 X 11 AA tandem repeats, O-glycosylated region	559..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832779
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740