Protein Alignment Est-P and Nlgn2

DIOPT Version :9

• Sequence 1: NP_788501.1
• Gene: Est-P / 39393
• FlyBaseID: FBgn0000594
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 626
• Identity: 161/626 - (25%)
• Similarity: 253/626 - (40%)
• Gaps: 161/626 - (25%)

  Fly    13 LWIAALESEADPLIVEITNGKIRGKDN-------GLYYSYESIPNAEHPTGALRFEAPQ-PYSHH 69
            |.:.:|..|..| :|....|::||...       |....:..:|.|..|.||.||:.|: |.|
  Rat    31 LGLGSLGEERFP-VVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPAS-- 92

  Fly    70 WTDVFNATQSPVECMQ-------------W-------------NQFINENNKLMGDEDCLTVSIY 108
            |..|.|||..|..|.|             |             ||          .||||.:::|
  Rat    93 WPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQ----------SEDCLYLNLY 147

  Fly   109 KP-------KKPNRSSF-------------PVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKI 153
            .|       ||.:.::.             ||::.||||::|.|:|:::....:...|.::|..:
  Rat   148 VPTEDGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATL 212

  Fly   154 SFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLH 218
            ::.||.|||.||||:...|||||.||..||:|:.:|||||||.|:.|.:.|..||.:..:|.:|.
  Rat   213 NYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILS 277

  Fly   219 EDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDI---- 279
            ...:.|.:.||:.||.|:..|.:.....:....|...|||...: |.|..:||:.|.:.::
  Rat   278 HHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDRED-STEAVECLRRKSSRELVDQD 341

  Fly   280 VSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQ 344
            |...|..:        ||||||:....||     ||..:::.|:|......:       |.|..:
  Rat   342 VQPARYHI--------AFGPVVDGDVVPD-----DPEILMQQGEFLNYDMLI-------GVNQGE 386

  Fly   345 LLERNKLTGESWIDLLNDRWFD-----WAPYLLFYRDAK----KTIKDM-----DDLSFDLRQQY 395
            .|:..:.:.|| .|.::...||     :...|..|.:.|    :|||.|     |..:.::|::.
  Rat   387 GLKFVEDSAES-EDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKT 450

  Fly   396 LADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPVYSFVYDNPTDSGVGQLLSNRTDV 460
            |.             .:|||..:.....:...||..| :||||.:.:.:...:      ..|.:
  Rat   451 LL-------------ALFTDHQWVAPAVATAKLHADY-QSPVYFYTFYHHCQA------EGRPE- 494

  Fly   461 HFGTVHGDDFFLIFN------TAAYRTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECN---- 515
            .....|||:...:|.      |..:......::.::|...:....:||..       |:.|
  Rat   495 WADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKT-------GDPNQPVP 552

  Fly   516 ------------FQNNV----NSKEYQVLRISRNACKNEEY 540
                        |:..|    ||||.|.|.|.......:.|
  Rat   553 QDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNY 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	156/608 (26%)
		Aes	<107..>240	CDD:223730	54/152 (36%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	158/615 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336374
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840