DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and ache

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_571921.1	Gene:	ache / 114549	ZFINID:	ZDB-GENE-010906-1	Length:	634	Species:	Danio rerio

Alignment Length:	552	Identity:	150/552 - (27%)
Similarity:	245/552 - (44%)	Gaps:	91/552 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SEADP-LIVEITNGKIRG-----KDNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQ 78
            ::|:| |:|....|:::|     .|.....::..||.||.|.|..||:..:| ...|.:||.|.:
Zfish    23 AQAEPDLVVATRLGRVQGTRLPVPDRSHVIAFLGIPYAEPPIGKRRFKRAEP-KKPWNNVFEAKE 86

  Fly    79 SPVECMQ--------------WNQFINENNKLMGDEDCLTVSIYKPKKPNRSSFPVVVLLHGGAF 129
            ....|.|              ||.     |::| .||||.::::.|..|...:..|:|.::||.|
Zfish    87 FSNACYQFVDTSYPGFPGIEMWNP-----NRVM-SEDCLYLNVWVPPTPRPQNLTVMVWIYGGGF 145

  Fly   130 MFGSGSIYGHDS--IMREGTLLVVKISFGLGPLGF-ASTGDRHLPGNYGLKDQRLALQWIKKNIA 191
            ..||.|:..:|.  :.....::||.:::.:|..|| |..|....|||.||.||||||||:::||.
Zfish   146 YSGSSSLDVYDGRYLAYTEKVVVVSMNYRVGAFGFLALNGSSDAPGNVGLYDQRLALQWVQENIH 210

  Fly   192 HFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPW--VIQQGGRRRAFELGR 254
            .|||.|..:.:.|.|||.||..:.:|..|.:.|...||..||....||  |.....|||..:||:
Zfish   211 FFGGNPKQVTIFGESAGAASVGMHVLSPDSRPLFTRAILQSGVPNTPWATVTFDEARRRTTKLGK 275

  Fly   255 IVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVI 319
            :|||...| ..||.|||::|...:::......|.:|.:...:|.|||:     ..|..:.|.|:|
Zfish   276 LVGCTWGN-DTELIDCLRNKHPQELIDQEWQVLPWSSLFRFSFVPVVD-----GVFFPDTPDAMI 334

  Fly   320 KSGKFAQVPWAVTYTTEDGG----YNAAQLLERNK--LTGESWIDLL-------ND--------R 363
            .||.|......:....::|.    |.|....:.|:  ::.|.:::.:       ||        :
Zfish   335 SSGNFKYTQILLGVNQDEGSYFLLYGAPGFSKDNESLISREDFLESVKMGVPHANDIGLEAVILQ 399

  Fly   364 WFDWAPYLLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTD--------VLFKN 420
            :.||    :...:.:|....|||:..|  |..:...:...:||.....:...        :.:.|
Zfish   400 YTDW----MDENNGQKNRDAMDDIVGD--QNVICPLQHFAKSYAQYAALHAQSSAAAPGTLGWGN 458

  Fly   421 SVPSAIDLHRKYGKSPVYSFVYDNPTDSGVGQLLSNRT-DVHFGTVHGDDFFLIFN-TAAYRTGI 483
            |.|:..:....:|  .||.:::|:..        ||.. ....|.:||.:...:|. ....|...
Zfish   459 SGPTGYNSGNSHG--AVYLYLFDHRA--------SNLAWPEWMGVIHGYEIEFVFGLPLEKRLNY 513

  Fly   484 RPDEEVISKKFIGMLEDFA------LNDKGTL 509
            ..:||.:|::.:....:||      :|..||:
Zfish   514 TAEEEKLSRRIMRYWANFARTGNPNVNTDGTM 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	147/545 (27%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	52/137 (38%)
ache	NP_571921.1	COesterase	23..583	CDD:278561	150/552 (27%)
ache	NP_571921.1	AChE_tetra	598..631	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575539
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840