DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Est-P and CES1

DIOPT Version :9

Sequence 1:NP_788501.1 Gene:Est-P / 39393 FlyBaseID:FBgn0000594 Length:544 Species:Drosophila melanogaster
Sequence 2:NP_001020366.1 Gene:CES1 / 1066 HGNCID:1863 Length:568 Species:Homo sapiens


Alignment Length:593 Identity:173/593 - (29%)
Similarity:257/593 - (43%) Gaps:111/593 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LW-----IAALESEA-------DPLIVEITNGKIRGKDNGLYYSYE----------SIPNAEHPT 55
            :|     :|.|.:.|       .|.:|:..:||:.||    :.|.|          .||.|:.|.
Human     1 MWLRAFILATLSASAAWAGHPSSPPVVDTVHGKVLGK----FVSLEGFAQPVAIFLGIPFAKPPL 61

  Fly    56 GALRFEAPQPYSHHWTDVFNATQSPVECMQ--------WNQFIN--ENNKLMGDEDCLTVSIYKP 110
            |.|||..||| :..|:.|.|||..|..|.|        ...|.|  ||..|...||||.::||.|
Human    62 GPLRFTPPQP-AEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTP 125

  Fly   111 ---KKPNRSSFPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPG 172
               .|.||  .||:|.:|||..|.|:.|.|...::.....::||.|.:.||..||.||||.|..|
Human   126 ADLTKKNR--LPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRG 188

  Fly   173 NYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALD 237
            |:|..||..||:|::.|||.|||.|.::.:.|.||||.|..:.:|....|:|...|||.||.||.
Human   189 NWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALT 253

  Fly   238 PWVIQQGG-RRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVV 301
            ..::::|. :..|.::....|| .|..||.:..||:.|...:::...   |...::.....|   
Human   254 SVLVKKGDVKPLAEQIAITAGC-KTTTSAVMVHCLRQKTEEELLETT---LKMKFLSLDLQG--- 311

  Fly   302 EPSDA--------PDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGY-NAAQL----LERNKLTG 353
            :|.::        ....|.:.|..:.....|..||:.|....::.|: ...||    |...:|..
Human   312 DPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQ 376

  Fly   354 ESWIDLLNDRWFDWAPYLLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLF 418
            ::.:.||      |..|.|.. .||:.|.       :..::||.....:|:.......:..||:|
Human   377 KTAMSLL------WKSYPLVC-IAKELIP-------EATEKYLGGTDDTVKKKDLFLDLIADVMF 427

  Fly   419 KNSVPSAIDL--HRKYGKSPVYSFVYD-NPTDSGVGQLLSNRTDVHFGTV---HGDDFFLIFNTA 477
              .|||.|..  ||..| :|.|.:.:. .|:.|         :|:...||   |||:.|.:|...
Human   428 --GVPSVIVARNHRDAG-APTYMYEFQYRPSFS---------SDMKPKTVIGDHGDELFSVFGAP 480

  Fly   478 AYRTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECNFQNNVNSKEYQ----VLRISRNA---- 534
            ..:.|...:|..:||..:....:||.|       |..|.:...:..||.    .|:|..|.    
Human   481 FLKEGASEEEIRLSKMVMKFWANFARN-------GNPNGEGLPHWPEYNQKEGYLQIGANTQAAQ 538

  Fly   535 -CKNEEYA 541
             .|::|.|
Human   539 KLKDKEVA 546

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Est-PNP_788501.1 Esterase_lipase 26..537 CDD:238191 165/562 (29%)
Aes <107..>240 CDD:223730 59/135 (44%)
CES1NP_001020366.1 COesterase 25..548 CDD:278561 168/569 (30%)
Aes <122..>240 CDD:223730 51/119 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142655
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000017
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11559
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.840

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