DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Est-P and CEL

DIOPT Version :9

Sequence 1:NP_788501.1 Gene:Est-P / 39393 FlyBaseID:FBgn0000594 Length:544 Species:Drosophila melanogaster
Sequence 2:NP_001798.3 Gene:CEL / 1056 HGNCID:1848 Length:753 Species:Homo sapiens


Alignment Length:527 Identity:171/527 - (32%)
Similarity:246/527 - (46%) Gaps:73/527 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LLCLTLLWIAALESEADPLIVEITNGKIRG--KDNGLYYS----YESIPNAEHPTGALRFEAPQP 65
            :|.||..|..|..::...:..|  .|.:.|  |..||...    ::.||.|. ||.||  |.|||
Human     8 VLGLTCCWAVASAAKLGAVYTE--GGFVEGVNKKLGLLGDSVDIFKGIPFAA-PTKAL--ENPQP 67

  Fly    66 YSHHWTDVFNATQSPVECMQWNQFINENNKLMGDEDCLTVSIYKP--KKPNRSSFPVVVLLHGGA 128
            :. .|.....|......|:|  ..|.::: ..||||||.::|:.|  :|......||::.::|||
Human    68 HP-GWQGTLKAKNFKKRCLQ--ATITQDS-TYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGA 128

  Fly   129 FMFGSGS--------IYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQW 185
            |:.|||.        :|..:.|...|.::||..::.:|||||.||||.:|||||||:||.:|:.|
Human   129 FLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAW 193

  Fly   186 IKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAF 250
            :|:|||.|||.|:||.|.|.||||||..||.|....|.|.:.|||.||.||.|||||:.....|.
Human   194 VKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAK 258

  Fly   251 ELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVR---SFLVFSYVPFSAFGPVVEPSDAPDAFLT 312
            ::...||| ....:|.:..|||......:..|.:   :.|.:..:.:..|.||::..     |:.
Human   259 KVAEKVGC-PVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGD-----FIP 317

  Fly   313 EDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLE-----RNKLTGESWIDLLNDRWFDWAPYLL 372
            .||..:..:.  |.:.:.......||...|:..:.     ..|:|.|.:..|:::  |.....| 
Human   318 ADPINLYANA--ADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSE--FTITKGL- 377

  Fly   373 FYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDL--HRKYGKS 435
              |.||.|        ||:..:..|...........|....|||||  .||:.|.|  ||...||
Human   378 --RGAKTT--------FDVYTESWAQDPSQENKKKTVVDFETDVLF--LVPTEIALAQHRANAKS 430

  Fly   436 -PVYSFVYDNPTDSGVGQLLSNRTDVH---FGTVHGDDFFLIFNTA-AYRTGIRPDEEVISKKFI 495
             ..|::::.:|          :|..|:   .|..|.||...:|... |..||.||.:..:||..|
Human   431 AKTYAYLFSHP----------SRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMI 485

  Fly   496 GMLEDFA 502
            ....:||
Human   486 AYWTNFA 492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Est-PNP_788501.1 Esterase_lipase 26..537 CDD:238191 166/508 (33%)
Aes <107..>240 CDD:223730 68/142 (48%)
CELNP_001798.3 Heparin-binding 21..121 32/108 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..753
17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type) 559..745
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142699
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D222591at33208
OrthoFinder 1 1.000 - - FOG0000017
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.750

Return to query results.
Submit another query.