DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Ces2a

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_598721.1	Gene:	Ces2a / 102022	MGIID:	2142491	Length:	558	Species:	Mus musculus

Alignment Length:	533	Identity:	149/533 - (27%)
Similarity:	239/533 - (44%)	Gaps:	82/533 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LCLTLLWIAAL------ESEADPLIVEITNGKIRG-----KD--NGLYYSYESIPNAEHPTGALR 59
            ||:....:..|      :..|.| |.....|::||     ||  :|: :::..||.|:.|.|.||
Mouse    10 LCVVACGLLLLLQHVHGQDSASP-IRNTHRGQVRGSFVHVKDTKSGV-HAFLGIPFAKPPVGLLR 72

  Fly    60 F---EAPQPYSHHWTDVFNATQSPVECMQWNQFINENNKLMG--------DEDCLTVSIYKPKKP 113
            |   |.|:|    |:.|.:.|..|..|:|.:....|:.|.|.        .||||.::||.|...
Mouse    73 FAPPEDPEP----WSGVRDGTSQPAMCLQPDIMNLEDAKEMNLILPPISMSEDCLYLNIYTPTHA 133

  Fly   114 NR-SSFPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLK 177
            .. |:.||:|.:|||..:.||.|:.....:.....:::|.|.:.||.|||.||||:|..||:|..
Mouse   134 QEGSNLPVMVWIHGGGLVVGSASMNDVSKLAATEEIVIVAIQYRLGVLGFFSTGDQHARGNWGYL 198

  Fly   178 DQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQ 242
            ||..||:|::||||:|||..|.:.:.|.||||.|....:|....|.|..|||..||.||.|.:|.
Mouse   199 DQVAALRWVQKNIAYFGGNRDRVTIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVALLPDLIS 263

  Fly   243 QGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAP 307
            .........:..:.||..|: |..|..||::|...:|::..:   ||..:|....|
Mouse   264 DTSEVVYKTVANLSGCEATD-SEALIHCLRAKSKQEILAINQ---VFKMIPAVVDG--------- 315

  Fly   308 DAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERN----KLTGESWIDLLNDRWFDWA 368
             .||.:.|:.::.|..|..||..:...|::.|:.....:..:    .:|.|:            .
Mouse   316 -EFLPKHPQELLTSMDFHPVPSIIGVNTDECGWGVPMFMGLDHIIKNITRET------------L 367

  Fly   369 PYLLFYRDAKKTIKDM---DDLSFDLRQQYLADRRFSVESYWNVQRMFTDVL--FKNSVPSAIDL 428
            |.:|     |.|...|   .:.|..|.::|:.|    .|....:|..|.::|  |...:|:....
Mouse   368 PAVL-----KNTAARMMLPPECSHLLVEEYMGD----TEDPETLQAQFREMLGDFMFVIPALQVA 423

  Fly   429 HRKYGKSPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAY--RTGIRPDEEVIS 491
            |.:..::|||.:.:.:     :...:.:....|....||||...:|.:..:  ...:..:||::.
Mouse   424 HFQRSQAPVYFYEFQH-----LSSFIKHVRPSHVKADHGDDVAFVFGSYLWDMNLDLTEEEELLK 483

  Fly   492 KKFIGMLEDFALN 504
            :..:....:||.|
Mouse   484 RMMMKYWANFARN 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	144/509 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	58/133 (44%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:278561	146/513 (28%)
Ces2a	NP_598721.1	Aes	<127..>230	CDD:223730	44/102 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832655
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850