DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Ces2

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001258232.1	Gene:	Ces2 / 100910144	RGDID:	6504334	Length:	561	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	148/545 - (27%)
Similarity:	247/545 - (45%)	Gaps:	85/545 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LCLTLLWIAALES-EADPLIVEITNGKIRGKDNGL------YYSYESIPNAEHPTGALRFEAPQP 65
            |.|.|:.:...:| |:.|:....| |:::||.:.:      .:::..||.|:.|.|.|||..|:|
  Rat    17 LLLLLIHVQGQDSPESSPIRTTHT-GQVQGKLDHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEP 80

  Fly    66 YSHHWTDVFNATQSPVECMQWNQFINE---------NNKLMGDEDCLTVSIYKPKKPNR-SSFPV 120
             ...|:.|.:||..|..|:|....::|         .:.:...||||.:::|.|..... |:.||
  Rat    81 -PEPWSGVRDATSQPAMCLQNLDILDEVGLLDMKMILSSISMSEDCLYLNVYAPAHAREGSNLPV 144

  Fly   121 VVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQW 185
            :|.:||||.:.|..|:|....:.....|:||.|.:.||.|||.||||.|..||:|..||..||:|
  Rat   145 MVWIHGGALVVGMASMYDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDEHARGNWGYLDQVAALRW 209

  Fly   186 IKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAF 250
            :::|||||||.|:.:.:.|.||||.|....::....:.|..|||..||.||.|.:|.:.....:.
  Rat   210 VQQNIAHFGGNPNRVTIFGESAGGTSVSSHVISPMSQGLFHGAIMESGVALLPDLISETSETVST 274

  Fly   251 ELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDP 315
            .:.::.||...: |..|..||::|..::|:...:   ||..:|....|          .||...|
  Rat   275 TVAKLSGCEAMD-SEALVRCLRAKSGAEILVINK---VFKMIPAVVDG----------EFLPRHP 325

  Fly   316 RAVIKSGKFAQVPWAVTYTTEDGGY--------NAAQLLERNKLTGESWIDLLNDRWFDWAPYLL 372
            :.::.|..|..||..:...|::  |        ..||:::  :|:.|:...:|.|.    |..::
  Rat   326 KELLASEDFHPVPSIIGVNTDE--YCCTIPMVMGTAQIIK--ELSRENLQAVLKDT----AAQMM 382

  Fly   373 FYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPV 437
            .       ..:..||   |.::|:.:...|.........|..|.||  .:|:....|.:...:||
  Rat   383 L-------PPECGDL---LMEEYMGNTDDSQTLQIQYTEMMGDFLF--VIPALQVAHFQRSHAPV 435

  Fly   438 YSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPD----EEVISKKFIGML 498
            |.:.:.:     ......|....|....|.|:...:|  .::.:|::.|    |.::|::.:...
  Rat   436 YFYEFQH-----APSYFKNVRPPHVKADHADEVPFVF--GSFFSGMKLDFTEEERLLSRRMMKYW 493

  Fly   499 EDFALNDKGTLTFGECNFQNNVNSK 523
            .:||.             |.|.||:
  Rat   494 ANFAR-------------QGNPNSE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	142/526 (27%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	58/133 (44%)
Ces2	NP_001258232.1	COesterase	31..540	CDD:278561	144/531 (27%)
Ces2	NP_001258232.1	Aes	<130..>233	CDD:223730	46/102 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336184
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830