DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and ache

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_002940088.1	Gene:	ache / 100490673	XenbaseID:	XB-GENE-923160	Length:	600	Species:	Xenopus tropicalis

Alignment Length:	593	Identity:	160/593 - (26%)
Similarity:	242/593 - (40%)	Gaps:	135/593 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LC-LTLLWIAALESEADPLIVEITNGKIRGKDNGLYYSYES----IPNAEHPTGALRFEAPQPYS 67
            || |:||.:.||......|:|...:||:||....:..::.|    ||.||.|...:||...:| .
Frog    11 LCTLSLLLVPALTQSDGGLLVSTRSGKVRGLRQPVLSTHVSAFLGIPFAEPPVDKMRFRRSEP-K 74

  Fly    68 HHWTDVFNATQSPVECMQ--------------WNQFINENNKLMGDEDCLTVSIYKPKKPNRSSF 118
            ..||||::||..|..|.|              ||.     |:.| .||||.::|:.| .|..|:.
Frog    75 KPWTDVWDATAYPNACYQYFDTLYPGFPGMEMWNP-----NRPM-SEDCLYLNIWVP-HPRPSNA 132

  Fly   119 PVVVLLHGGAFMFGSGSIYGHDS--IMREGTLLVVKISFGLGPLGF--ASTGDRHLPGNYGLKDQ 179
            .|:|.::||.|..||.|:..:|.  :.....::||.:::.:|..||  .:.|....|||.||.||
Frog   133 TVMVWIYGGGFYSGSSSLDVYDGRYLCHAENVIVVSMNYRVGAFGFLTLTPGSVDAPGNVGLFDQ 197

  Fly   180 RLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPW--VIQ 242
            ||||||::.|||.|||.|..:.:.|.|||..|..:.:|.....||...|...||:...||  :..
Frog   198 RLALQWVQDNIAFFGGDPRTVTIFGESAGAVSVGMHVLSPGSHHLFSKAALQSGSPNTPWATITP 262

  Fly   243 QGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFL----VFSYVPFSAFGPVVEP 303
            |..|||...||:.:.|...| ..||.:||:.|...:::....|.|    ||.:    ||.||
Frog   263 QEARRRTELLGKFLDCRMGN-DTELLNCLRVKQPQELIDHEFSVLPAPSVFRF----AFVPV--- 319

  Fly   304 SDAPDA-FLTEDPRAVIKSGKFAQVPWAVTYTTEDGGY-----------NAAQLLERNKLTGESW 356
               ||| |..|.|..::..|:|...|..:.....:|.|           |...|:.|.:..|
Frog   320 ---PDADFFPEPPEILMNMGRFKPCPLIMGVNQNEGSYFLLYGAPGFSKNNESLITREEFLG--- 378

  Fly   357 IDLLNDRWFDWAPYLLFYRDAKKTIKDMDDLSFD-LRQQYL--ADRRFSVESYWNVQRMFTD--- 415
                               ..|.::...:|::.: :..||.  ||....|::...:.::..|
Frog   379 -------------------GVKMSVPQANDIALEAVVMQYTDWADEHAGVKNREAMDQLVGDHNV 424

  Fly   416 ----VLFKNSVPSAIDLHRKYGKSPVYSFVYDNPTDSGVGQLLSNRT-DVHFGTVHGDDFFLIFN 475
                ..|...|...        .:.||::.:|:..        ||.. ....|..||.:...:|.
Frog   425 ICPLTYFAGKVAET--------GNRVYTYFFDHRA--------SNLAWPQWMGVPHGYEIEFVFG 473

  Fly   476 TAA-YRTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECNFQNN------------------VN 521
            ... ......|.||.:|::.:....:||..       |:.|..|:                  :|
Frog   474 LPLDANLNYTPQEEALSRRMMRYWANFART-------GDPNEGNDAHQPRWPLYTASEQRYMALN 531

  Fly   522 SKEYQVLR 529
            :|.||.|:
Frog   532 NKPYQELQ 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	152/574 (26%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	52/138 (38%)
ache	XP_002940088.1	COesterase	31..549	CDD:395084	152/573 (27%)
ache	XP_002940088.1	AChE_tetra	564..597	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910