DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Est-6 and CES2

DIOPT Version :9

Sequence 1:NP_001261749.1 Gene:Est-6 / 39392 FlyBaseID:FBgn0000592 Length:544 Species:Drosophila melanogaster
Sequence 2:NP_001352334.1 Gene:CES2 / 8824 HGNCID:1864 Length:559 Species:Homo sapiens


Alignment Length:552 Identity:152/552 - (27%)
Similarity:238/552 - (43%) Gaps:108/552 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MNYVGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGR------DNGSYYSYESIPYAEPPTG 59
            ::.|..||:::|    :.....|:..|:.. ...|::.|.      .|....::..||:|:||.|
Human    10 LSAVACGLLLLL----VRGQGQDSASPIRT-THTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLG 69

  Fly    60 DLRFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGE-----------EDCLTVSVYKP 113
            .|||..||| .:.||.:.|.|..|..|||  ..|...::.:.:           ||||.:|:|.|
Human    70 PLRFAPPEP-PESWSGVRDGTTHPAMCLQ--DLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTP 131

  Fly   114 KNSKRNS-FPVVAHIHGGAFMFG-AAWQNGH-----ENVMREGKFILVKISYRLGPLGFVSTGDR 171
            .:|...| .||:..|||||.:|| |:..:|.     |||      ::|.|.||||.|||.||||:
Human   132 AHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENV------VVVIIQYRLGVLGFFSTGDK 190

  Fly   172 DLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSG 236
            ...||:|..||..||:|::||||.|||.|..|.:.|.||||.||...::......|...|...||
Human   191 HATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESG 255

  Fly   237 NALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFS 301
            .||.|.:|...|...:..:.....|:.. ||.:|..||:.|...|:: |:.|          ||.
Human   256 VALLPGLIASSADVISTVVANLSACDQV-DSEALVGCLRGKSKEEIL-AINK----------PFK 308

  Fly   302 PVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWL 366
            .:  |.......:.:.|::::.|..|..||..|.....:.|:                       
Human   309 MI--PGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGW----------------------- 348

  Fly   367 ELAPYLLFYRDTKTKKDMD-------------------DYSRKIKQEYIGNQRFDIESYSELQRL 412
             |.|.::...|  |:|:||                   .:...:::||||:........::.|.:
Human   349 -LIPKVMRIYD--TQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEM 410

  Fly   413 FTDILFKNSTQESLDL-HRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFEN 476
            ..|.:|   ...:|.: |.:..::|.|.|.:.:.     ...|.|.........|||:...:|.:
Human   411 MADSMF---VIPALQVAHFQCSRAPVYFYEFQHQ-----PSWLKNIRPPHMKADHGDELPFVFRS 467

  Fly   477 FV--RDVEMRPDEQIISRNFINMLADFASSDN 506
            |.  ..::...:|:.:||..:...|:||.:.|
Human   468 FFGGNYIKFTEEEEQLSRKMMKYWANFARNGN 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Est-6NP_001261749.1 Esterase_lipase 29..537 CDD:238191 146/524 (28%)
Aes <110..>243 CDD:223730 62/139 (45%)
CES2NP_001352334.1 COesterase 30..538 CDD:306613 147/528 (28%)
Prevents secretion from ER. /evidence=ECO:0000255 556..559
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142676
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000017
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11559
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.840

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