Protein Alignment Est-6 and Ces1h

DIOPT Version :9

• Sequence 1: NP_001261749.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_001357759.1
• Gene: Ces1h / 75704
• MGIID: 1922954
• Length: 562
• Species: Mus musculus
• Alignment Length: 562
• Identity: 157/562 - (27%)
• Similarity: 243/562 - (43%)
• Gaps: 124/562 - (22%)

  Fly     8 LIIVLSCL-WLGSNASDTDDPLLVQLPQGKLRGRDNGSYYSYE----------SIPYAEPPTGDL 61
            :::.||.: |.|..:|    |.:|....||:.|:    |.|.|          .:|:|:||.|.|
Mouse     7 ILLSLSAMAWGGYPSS----PPVVNTTHGKVLGK----YISLEGFTQPVAVFLGVPFAKPPLGSL 63

  Fly    62 RFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLV----------GEEDCLTVSVYKP--- 113
            ||..|:| .:.||.:.:||..|..|.|........|.|:          ..||||.::||.|
Mouse    64 RFAPPQP-PEPWSFVKNATSYPPMCSQDAVLGQMVNDLIINNKEKIRLRFSEDCLYLNVYTPVDL 127

  Fly   114 -KNSKRNSFPVVAHIHGGAFMFGAA------WQNGHENVMREGKFILVKISYRLGPLGFVSTGDR 171
             ||:  |..||:..||||..:.|.|      ..:.||||      ::|.|.|||...||.||||.
Mouse   128 MKNT--NRLPVMVWIHGGGLVVGGASAYDGRTLSAHENV------VVVTIQYRLAIWGFFSTGDE 184

  Fly   172 DLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSG 236
            ...||:|..||..||.||:.|||:|||:|.:|.:.|.||||.||.:.:|......|...|.|.||
Mouse   185 HSRGNWGHLDQLAALHWIQDNIANFGGDPGSVTIFGQSAGGESVSVLVLSPLAKNLFHRAISQSG 249

  Fly   237 NALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSY------- 294
            ......:..:.|.....::....||::. .|..:..||:.|...||:..::|..:|..
Mouse   250 VVFTSGLFMEDASSVTEQIAVTAGCKTT-TSAVIVHCLRQKTEEELLEIMQKMNLFKLDAQENTK 313

  Fly   295 --VPFAP--FSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSG 355
              .||.|  ...|:.|. ||:||:.:.        .|..||:.|....::.|:...::::...:.
Mouse   314 KNYPFLPTVLDGVVLPK-APEAILAEK--------NFNTVPYIVGINKQEFGWTLPMIMEFPPTD 369

  Fly   356 IVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFD-----IESYSE------- 408
            :.:|                     ||.:..:.||:  .|..|...|     ||.||:
Mouse   370 VKLD---------------------KKVISLFLRKL--AYFFNIPEDGIPVAIEKYSKGTDDPIQ 411

  Fly   409 ----LQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRT---DYDFGTVH 466
                |.:|..|::|   ...|:.:.|.:..:.|..|:|:..:....:..|..:|   |      |
Mouse   412 NRVWLLQLIGDVMF---GIPSVIVSRGHRDAGAPTYMYEFQSRPSFSSELKPKTVTGD------H 467

  Fly   467 GDDYFLIF-ENFVRDVEMRPDEQI-ISRNFINMLADFASSDN 506
            ||:.:.:| ...:|  |...:|:| :|:..:...|:||.:.|
Mouse   468 GDEVYSVFGAPILR--EGSSEEEINLSKMMMKFWANFARNGN 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	151/540 (28%)
		Aes	<110..>243	CDD:223730	59/142 (42%)
Ces1h	NP_001357759.1	COesterase	24..546	CDD:365897	151/541 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832538
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840