DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Est-6 and TG

DIOPT Version :9

Sequence 1:NP_001261749.1 Gene:Est-6 / 39392 FlyBaseID:FBgn0000592 Length:544 Species:Drosophila melanogaster
Sequence 2:NP_003226.4 Gene:TG / 7038 HGNCID:11764 Length:2768 Species:Homo sapiens


Alignment Length:543 Identity:137/543 - (25%)
Similarity:227/543 - (41%) Gaps:102/543 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 GKLRGRDN----GSYY----SYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQWDQ 91
            |:|.||..    |:.:    .:..:|||.||..:.||:||||.  .|:..:||:|...:|  |..
Human  2207 GRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPL--NWTGSWDASKPRASC--WQP 2267

  Fly    92 FT-----PGANKLVGEEDCLTVSVYKPKNSKRNSFPVVAHIHG--------------GAFMFGAA 137
            .|     ||.:     ||||.::|:.|:|...|: .|:...|.              |:|:... 
Human  2268 GTRTSTSPGVS-----EDCLYLNVFIPQNVAPNA-SVLVFFHNTMDREESEGWPAIDGSFLAAV- 2325

  Fly   138 WQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQN 202
                       |..|:|..|||:|..||:|:|..::.||:||.||..||.|::.:|..|||:|:.
Human  2326 -----------GNLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRR 2379

  Fly   203 VLLVGHSAGG--ASVHLQMLREDFGQLARAAFSFSGNALDPWVI--QKGARGRAFELGRNVGCES 263
            |.|.....|.  ||:||...|....||.|.|....|:||.|..:  .:.|:.:|..|.:.|.|..
Human  2380 VSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPM 2444

  Fly   264 AEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFG 328
            : .|..:..||:.|||:.|..|..|.|..| .||..:.||::     ...:.:.|...:|...:.
Human  2445 S-SSQEVVSCLRQKPANVLNDAQTKLLAVS-GPFHYWGPVID-----GHFLREPPARALKRSLWV 2502

  Fly   329 QVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQ 393
            :|...:....:||..|.|..:|:         ..|.....:....||:..:.....:|...::  
Human  2503 EVDLLIGSSQDDGLINRAKAVKQ---------FEESRGRTSSKTAFYQALQNSLGGEDSDARV-- 2556

  Fly   394 EYIGNQRFDIESYSELQRLFTDILFKNSTQE------SLDLHRKYGK-SPAYAYVYDNPAE--KG 449
            |......:.:|..::....|:..| :|:|::      .:|:...:.| :....::|..|..  .|
Human  2557 EAAATWYYSLEHSTDDYASFSRAL-ENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHG 2620

  Fly   450 IAQVLANRTDYDFGTVHGDDYFLIFENFVRDVEMRPDEQIISRNFINMLADFASSDNGSLKYGEC 514
            ..::||   |..|..  |..::..:|.     :...:|:.:|...:...:.|..|.|.:..|...
Human  2621 SLELLA---DVQFAL--GLPFYPAYEG-----QFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFS 2675

  Fly   515 -----------DFKDNVGSEKFQ 526
                       ||....|.|.::
Human  2676 RKVPTFATPWPDFVPRAGGENYK 2698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Est-6NP_001261749.1 Esterase_lipase 29..537 CDD:238191 137/543 (25%)
Aes <110..>243 CDD:223730 49/148 (33%)
TGNP_003226.4 TY 33..92 CDD:238114
TY 95..160 CDD:238114
TY 300..358 CDD:238114
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..545
Thyroglobulin_1 599..658 CDD:395039
Thyroglobulin_1 662..724 CDD:395039
TY 729..>776 CDD:412186
TY <892..922 CDD:412186
TY 1004..1073 CDD:238114
TY 1077..1145 CDD:238114
TY 1149..1210 CDD:238114
Type II. /evidence=ECO:0000269|PubMed:8797845 1456..1469
Ephrin_rec_like 1465..1510 CDD:400166
Type II. /evidence=ECO:0000269|PubMed:8797845 1470..1486
Type II. /evidence=ECO:0000269|PubMed:8797845 1487..1503
TY 1520..1567 CDD:214561
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 1603..1723
Type IIIB. /evidence=ECO:0000269|PubMed:8797845 1724..1892
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 1893..1995
Type IIIB. /evidence=ECO:0000269|PubMed:8797845 1996..2129
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 2130..2187
Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710 2188..2768 137/543 (25%)
COesterase 2197..2718 CDD:395084 137/543 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2727..2768
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142706
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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