Protein Alignment Est-6 and TG

DIOPT Version :10

• Sequence 1: NP_788500.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_003226.4
• Gene: TG / 7038
• HGNCID: 11764
• Length: 2768
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 137/543 - (25%)
• Similarity: 227/543 - (41%)
• Gaps: 102/543 - (18%)

  Fly    35 GKLRGRDN----GSYY----SYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQWDQ 91
            |:|.||..    |:.:    .:..:|||.||..:.||:||||.  .|:..:||:|...:|  |..
Human  2207 GRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPL--NWTGSWDASKPRASC--WQP 2267

  Fly    92 FT-----PGANKLVGEEDCLTVSVYKPKNSKRNSFPVVAHIHG--------------GAFMFGAA 137
            .|     ||.:     ||||.::|:.|:|...|: .|:...|.              |:|:...
Human  2268 GTRTSTSPGVS-----EDCLYLNVFIPQNVAPNA-SVLVFFHNTMDREESEGWPAIDGSFLAAV- 2325

  Fly   138 WQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQN 202
                       |..|:|..|||:|..||:|:|..::.||:||.||..||.|::.:|..|||:|:.
Human  2326 -----------GNLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRR 2379

  Fly   203 VLLVGHSAGG--ASVHLQMLREDFGQLARAAFSFSGNALDPWVI--QKGARGRAFELGRNVGCES 263
            |.|.....|.  ||:||...|....||.|.|....|:||.|..:  .:.|:.:|..|.:.|.|..
Human  2380 VSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPM 2444

  Fly   264 AEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFG 328
            : .|..:..||:.|||:.|..|..|.|..| .||..:.||::     ...:.:.|...:|...:.
Human  2445 S-SSQEVVSCLRQKPANVLNDAQTKLLAVS-GPFHYWGPVID-----GHFLREPPARALKRSLWV 2502

  Fly   329 QVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQ 393
            :|...:....:||..|.|..:|:         ..|.....:....||:..:.....:|...::
Human  2503 EVDLLIGSSQDDGLINRAKAVKQ---------FEESRGRTSSKTAFYQALQNSLGGEDSDARV-- 2556

  Fly   394 EYIGNQRFDIESYSELQRLFTDILFKNSTQE------SLDLHRKYGK-SPAYAYVYDNPAE--KG 449
            |......:.:|..::....|:..| :|:|::      .:|:...:.| :....::|..|..  .|
Human  2557 EAAATWYYSLEHSTDDYASFSRAL-ENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHG 2620

  Fly   450 IAQVLANRTDYDFGTVHGDDYFLIFENFVRDVEMRPDEQIISRNFINMLADFASSDNGSLKYGEC 514
            ..::||   |..|..  |..::..:|.     :...:|:.:|...:...:.|..|.|.:..|...
Human  2621 SLELLA---DVQFAL--GLPFYPAYEG-----QFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFS 2675

  Fly   515 -----------DFKDNVGSEKFQ 526
                       ||....|.|.::
Human  2676 RKVPTFATPWPDFVPRAGGENYK 2698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_788500.1	Esterase_lipase	29..537	CDD:238191	137/543 (25%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:459665
		Thyroglobulin_1	662..724	CDD:459665
		TY	730..>776	CDD:469630
		TY	<892..922	CDD:469630
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:429604
		Type II. /evidence=ECO:0000269|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	2130..2187
		Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710	2188..2768		137/543 (25%)
		COesterase	2197..2718	CDD:395084	137/543 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2727..2768