DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Ces2j

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_038953911.1	Gene:	Ces2j / 685645	RGDID:	1591368	Length:	576	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	152/517 - (29%)
Similarity:	237/517 - (45%)	Gaps:	67/517 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WLGSNASDTDDPLLVQLPQGKLRG-----RDNGS-YYSYESIPYAEPPTGDLRF---EAPEPYKQ 71
            :|.....|:..|:. ....|::||     :|..| .:::..||:|:||.|.|||   |.|||
  Rat    41 FLTEQGQDSASPIR-NTHTGQVRGSFVHVKDTKSGIHTFLGIPFAKPPVGPLRFAPPEDPEP--- 101

  Fly    72 KWSDIFDATKTPVACLQWDQFTPGAN----------KLVGEEDCLTVSVYKPKNSKRNS-FPVVA 125
             ||.:.|||..|..|||    |...|          ||...||||.:::|.|.::..:| .||:.
  Rat   102 -WSGVRDATSQPAMCLQ----TAMMNLEGMKETELTKLPMSEDCLYLNIYVPAHAHEDSNLPVMV 161

  Fly   126 HIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIK 190
            .||||..:.|:|..|....:....:.::|.|.||||.|||.||||:...||:|..||..||:|::
  Rat   162 WIHGGGLVGGSASMNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQHARGNWGYLDQMAALRWVQ 226

  Fly   191 QNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFEL 255
            ||||.|||...:|.:.|.||||.||...::......|...|...||.||.|.:|...:......:
  Rat   227 QNIAYFGGNRDSVTIFGVSAGGTSVSSHVVSPMSKGLFHRAIMQSGVALLPGLISDTSEVVYKTV 291

  Fly   256 GRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRD 320
            ....||| |.||.:|.:||::|...|::...:.|.:...|....|.|             :.|::
  Rat   292 ANLSGCE-ASDSEALIRCLRAKSKQEILAINQVFKMIPGVVDGKFLP-------------KHPQE 342

  Fly   321 VIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGI--VIDDLNERWLELAPYLLFYRDTKTKKD 383
            ::.|..|..||..:...|::.|:....:|     |:  :|:::....|..|..:...:.....:.
  Rat   343 LLASKDFHPVPSIIGVNTDECGWGVPTIL-----GLYHIINNITRETLPAALKIAAAQMMLPPEC 402

  Fly   384 MDDYSRKIKQEYIGNQRFDIESYSELQRLFTDIL--FKNSTQESLDLHRKYGKSPAYAYVYDNPA 446
            :|    .|.:||:|    |.|....||..|.::|  |..........|.:..::|.|.|.:.: .
  Rat   403 ID----LIMEEYMG----DTEDAETLQAQFKEMLGDFIFVIPALQVAHFQRSQAPVYFYEFQH-L 458

  Fly   447 EKGIAQVLANRTDYDFGTVHGDDYFLIFENFV--RDVEMRPDEQIISRNFINMLADFASSDN 506
            ...|.||.......|    ||||...:|.::.  ...::..:|:::.|..:...|:||.:.|
  Rat   459 LSFIKQVRPFYPKAD----HGDDTVFVFGSYFWGMTFDLTEEEELLKRRVMKYWANFARTGN 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	149/504 (30%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	55/133 (41%)
Ces2j	XP_038953911.1	COesterase	50..555	CDD:395084	150/508 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850