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Protein Alignment Est-6 and BCHE

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_000046.1	Gene:	BCHE / 590	HGNCID:	983	Length:	602	Species:	Homo sapiens

Alignment Length:	555	Identity:	161/555 - (29%)
Similarity:	261/555 - (47%)	Gaps:	118/555 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VLSCLWLGSNASDTDDPLLVQLPQGKLRGRD----NGSYYSYESIPYAEPPTGDLRFEAPEPYKQ 71
            :|.|:.:|.  |.|:|.:::....||:||.:    .|:..::..||||:||.|.|||:.|:.. .
Human    17 LLLCMLIGK--SHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSL-T 78

  Fly    72 KWSDIFDATKTPVACLQ-WDQFTPGANKLVG----------EEDCLTVSVY----KPKNSKRNSF 121
            |||||::|||...:|.| .||..||.:   |          .||||.::|:    ||||:
Human    79 KWSDIWNATKYANSCCQNIDQSFPGFH---GSEMWNPNTDLSEDCLYLNVWIPAPKPKNA----- 135

  Fly   122 PVVAHIHGGAFMFGAAWQNGHENVMREGKF-------ILVKISYRLGPLGFVS-TGDRDLPGNYG 178
            .|:..|:||.|..|.:..:     :.:|||       |:|.::||:|.|||:: .|:.:.|||.|
Human   136 TVLIWIYGGGFQTGTSSLH-----VYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMG 195

  Fly   179 LKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWV 243
            |.||:|||:|:::|||:|||.|::|.|.|.|||.|||.|.:|......|...|...||:...||.
Human   196 LFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWA 260

  Fly   244 IQK--GARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPF-APFSPVLE 305
            :..  .||.|...|.:..|| |.|:.|.:.|||::|...|::  :.:..:   ||: .|.|....
Human   261 VTSLYEARNRTLNLAKLTGC-SRENETEIIKCLRNKDPQEIL--LNEAFV---VPYGTPLSVNFG 319

  Fly   306 PSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGG-----YNAALLLKERKSGIVIDDLNERW 365
            |:...| .:|..|..:::.|:|.:....|. |.:|.|     |.|....|:..|.|...:..|..
Human   320 PTVDGD-FLTDMPDILLELGQFKKTQILVG-VNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGL 382

  Fly   366 LELAP---------YLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNS 421
            ....|         .|..|.|....:..::| |:...:.:|:..|
Human   383 KIFFPGVSEFGKESILFHYTDWVDDQRPENY-REALGDVVGDYNF-------------------- 426

  Fly   422 TQESLDLHRKYGK--SPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIF-------ENF 477
            ...:|:..:|:.:  :.|:.|.:::.:.|      ....:: .|.:||.:...:|       :|:
Human   427 ICPALEFTKKFSEWGNNAFFYYFEHRSSK------LPWPEW-MGVMHGYEIEFVFGLPLERRDNY 484

  Fly   478 VRDVEMRPDEQIISRNFINMLADFASSDNGSLKYG 512
            .:      .|:|:||:.:...|:||       |||
Human   485 TK------AEEILSRSIVKRWANFA-------KYG 506

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.