DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-6 and NLGN2

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_065846.1	Gene:	NLGN2 / 57555	HGNCID:	14290	Length:	835	Species:	Homo sapiens

Alignment Length:	505	Identity:	139/505 - (27%)
Similarity:	205/505 - (40%)	Gaps:	98/505 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LVQLPQGKLRG----RDN---GSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVAC 86
            :|....|::||    .:|   |....:..:|||.||.|..||:.||. ...|..:.:||..|.||
Human    43 VVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEA-PASWPGVRNATTLPPAC 106

  Fly    87 LQ-------------W--DQFTPGANKLVGE-EDCLTVSVYKPK-----NSKRNSF--------- 121
            .|             |  |.....|..:..: ||||.:::|.|.     ..||:..
Human   107 PQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDI 171

  Fly   122 ------PVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLK 180
                  ||:..:|||::|.|.........:...|..|:..::||||.|||:||||:...|||||.
Human   172 RDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLL 236

  Fly   181 DQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQ 245
            ||..||:|:.:|||.|||:|:.:.:.|..||.:.|:|.:|......|.:.|.:.||.|:..|.:.
Human   237 DQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVN 301

  Fly   246 KGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELV---TAVRKFLIFSYVPFAPFSPVLEPS 307
            .........|...|||: .|||....:||:.||:.|||   ....::.|       .|.||::..
Human   302 YQPLKYTRLLAAKVGCD-REDSAEAVECLRRKPSRELVDQDVQPARYHI-------AFGPVVDGD 358

  Fly   308 DAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLK------ERKSGIVIDDLNERWL 366
            ..||     ||..:::.|:|......:       |.|....||      |.:.|:.....:....
Human   359 VVPD-----DPEILMQQGEFLNYDMLI-------GVNQGEGLKFVEDSAESEDGVSASAFDFTVS 411

  Fly   367 ELAPYLLFYRDTKTKKDMDDYSRKIKQEYI-------GNQRFDIESYSELQRLFTDILFKNSTQE 424
            .....|..|.:.|     |.....||..|.       |..|     ...|..||||..:......
Human   412 NFVDNLYGYPEGK-----DVLRETIKFMYTDWADRDNGEMR-----RKTLLALFTDHQWVAPAVA 466

  Fly   425 SLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIF 474
            :..||..| :||.|.|.:.:..:      ...|.:: ....|||:...:|
Human   467 TAKLHADY-QSPVYFYTFYHHCQ------AEGRPEW-ADAAHGDELPYVF 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	139/505 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	52/152 (34%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	139/505 (28%)
		Aes	<170..>268	CDD:223730	39/97 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..835
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142704
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740