Protein Alignment Est-6 and NLGN4X

DIOPT Version :10

• Sequence 1: NP_788500.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 157/565 - (27%)
• Similarity: 237/565 - (41%)
• Gaps: 118/565 - (20%)

  Fly     6 LGLIIVLSCLWLGSNA---------------SDTDDPLLVQLPQGKLRGRDN-------GSYYSY 48
            |.|:....|:.|.||.               |....| :|....||:||...       |....|
Human    10 LPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYP-VVNTNYGKIRGLRTPLPNEILGPVEQY 73

  Fly    49 ESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQ--------------WDQFTPGANKL 99
            ..:|||.||||:.||:.||| ...|:.|.:.|:....|.|              |  ||...:.|
Human    74 LGVPYASPPTGERRFQPPEP-PSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIW--FTANLDTL 135

  Fly   100 V-----GEEDCLTVSVYKP----KNSKRNS--------------------FPVVAHIHGGAFMFG 135
            :     ..||||.:::|.|    .|:|:|:                    .||:.:||||::|.|
Human   136 MTYVQDQNEDCLYLNIYVPTEDGANTKKNADDITSNDRGEDEDIHDQNSKKPVMVYIHGGSYMEG 200

  Fly   136 AAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEP 200
            .........:...|..|::.|:||||.|||:||||:...|||||.||..||:||::|:.:|||:|
Human   201 TGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDP 265

  Fly   201 QNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVGCESAE 265
            :.|.:.|..||.:.|.|..|......|.:.|...||.||..|.:..........|...|||...
Human   266 KRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNML- 329

  Fly   266 DSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQV 330
            |:|.:.:||::|...||:...    |........|.||::....||     ||:.:::.|:|
Human   330 DTTDMVECLRNKNYKELIQQT----ITPATYHIAFGPVIDGDVIPD-----DPQILMEQGEF--- 382

  Fly   331 PWAVSY-----VTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFY---RDT--KTKKDM- 384
               ::|     |.:..|......:.:.:.|:..:|.:.........|..|   :||  :|.|.|
Human   383 ---LNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMY 444

  Fly   385 DDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKG 449
            .|::.|...|   .:|      ..|..||||..:......:.|||.:|| ||.|.|.:.:..:..
Human   445 TDWADKENPE---TRR------KTLVALFTDHQWVAPAVATADLHAQYG-SPTYFYAFYHHCQSE 499

  Fly   450 IAQVLANRTDYDFGTVHGDDYFLIFENFVRDVEMRPDEQIISRNF 494
            :....|:       :.|||:...:|     .:.|....::.|.||
Human   500 MKPSWAD-------SAHGDEVPYVF-----GIPMIGPTELFSCNF 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_788500.1	Esterase_lipase	29..537	CDD:238191	149/527 (28%)
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	150/531 (28%)