DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and tg

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001316794.1	Gene:	tg / 567631	ZFINID:	ZDB-GENE-030519-1	Length:	2733	Species:	Danio rerio

Alignment Length:	537	Identity:	138/537 - (25%)
Similarity:	229/537 - (42%)	Gaps:	82/537 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LRGRDNGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVG 101
            :.|.|:.....:..:|||.||.|||||..|:|  ..|:..::||....:|||....|..::
Zfish  2183 ITGSDSKRVTYFLGVPYARPPIGDLRFSPPQP--ADWTGTWNATFFRSSCLQPGDLTDSSS---- 2241

  Fly   102 EEDCLTVSVYKPKNSKRNSFPVVAHIH-GGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGF 165
            .||||.::|:...:..:|: ||:...| .|:.:...::      :...|..|:|..|:|:...||
Zfish  2242 SEDCLYLNVFVASSVAKNA-PVLVFFHNSGSDLLDGSY------LAAVGNIIVVTASFRMAAFGF 2299

  Fly   166 VSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASV-HLQMLREDFGQLAR 229
            :|.|...|||||||:||..||.|:::|||.|||:|..| .||....||.: .|.:.......|..
Zfish  2300 LSAGSSALPGNYGLQDQAAALGWVQKNIALFGGDPTKV-TVGAERNGADIASLHLTSPSASSLFS 2363

  Fly   230 AAFSFSGNALDPWVIQKGARGRA--FELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIF 292
            .|....|:...|.|:...::.:|  ..|.|.:.|::| |.:.|..||:||||..:..|..|.|..
Zfish  2364 RALLMGGSVFSPAVVMSSSKAQAQTSSLARELDCQAA-DPSQLLDCLRSKPAHSINAAQTKLLAV 2427

  Fly   293 SYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLK--ERKSG 355
            | .|...:|||::.:     ::.:.|...::||:|.:....:....|||..:.|..:|  |:..|
Zfish  2428 S-GPLQAWSPVVDGN-----VVREMPSVALQSGRFHKAEILLGSSFEDGLISRAKNIKNFEQLQG 2486

  Fly   356 ---------------IVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIES 405
                           :..||.|....|.|.:....:.:.|....:.:||
Zfish  2487 RADSKTAFYAALSNSLGGDDANAFVKEAATWFYSLQHSPTPSGYNVFSR---------------- 2535

  Fly   406 YSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAY-VYDNPAEKGIAQVLANRTDYDFGTVHGDD 469
              .|:....|:.....|.:..:......::..|.| :.:|.|...:...:.....|.||..
Zfish  2536 --ALENATRDLFIICPTVDMAEFWAANTQTGVYMYHLPENAAYNSVDLSVPMDVQYLFGVP---- 2594

  Fly   470 YFLIFENFVRDVEMRPDEQIISRNFINMLADFASSDNGSL-------KYGEC-----DFKDNVGS 522
              |..|.  ||: ....|:..:...:|.:|:|..|.|.:|       .:|:.     .|..:||.
Zfish  2595 --LAAEQ--RDL-FSYKEKTFTLQIMNYMANFIKSGNPNLPLAASRTSFGKFLPPWPQFMPHVGG 2654

  Fly   523 EKFQLLAIYIDGCQNRQ 539
            ..::.|:..:...:|.|
Zfish  2655 RAYKELSSTLVNRKNLQ 2671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	136/533 (26%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	44/134 (33%)
tg	NP_001316794.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575542
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930