DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and ces2b

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	545	Identity:	157/545 - (28%)
Similarity:	240/545 - (44%)	Gaps:	101/545 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IIVLSCLWLGSNASDTDDPLLVQLPQG-------KLRGRDNGSYYSYESIPYAEPPTGDLRFEAP 66
            :.:|..:.|.::....|.|:| |...|       |.||:|. ..:||..||:|:||.|.||...|
Zfish    11 LCILIAVTLQNSVKAEDGPIL-QTNSGALKGLQMKARGKDT-VIHSYLGIPFAKPPVGPLRLAPP 73

  Fly    67 EPYKQKWSDIFDATKTPVACLQWDQ--------FTPGANKLVGEEDCLTVSVYKPKNSKRN-SFP 122
            :| .:||..:.||||.|:.|||..|        .:...:.:...||||.::||.|....|| ..|
Zfish    74 QP-AEKWEGVRDATKQPLMCLQDRQLVEDLVANLSAKVDMVDSSEDCLYLNVYTPSKPGRNDKLP 137

  Fly   123 VVAHIHGGAF-MFGAAWQNGH-----ENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKD 181
            |:..||||.| ...|:..:||     ::|      ::|.|.||||.|||.||||.:.||||||.|
Zfish   138 VMVWIHGGGFTTCSASLFDGHVLAAYQDV------VVVVIQYRLGLLGFFSTGDENAPGNYGLLD 196

  Fly   182 QRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQK 246
            |..||:|:::||.||||:|.:|.:.|.||||.||.|.:|......|...|.:.||.|....::..
Zfish   197 QVAALQWVQENIHSFGGDPGSVTIFGESAGGISVSLHVLSPLSANLFHRAIAESGTAAMEAIMNV 261

  Fly   247 GARGRAFELGRNVGCESAEDSTSLKK---CLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSD 308
            .....|..:|...||    |.:|.||   ||..|...|::....:..:|.      |...::...
Zfish   262 NPLPIAQAIGNASGC----DISSTKKIVDCLMQKSEVEILKITMENPLFR------FGVTIDGQF 316

  Fly   309 APDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDD--LNERWL----- 366
            .|     :...::.:|.:|.:|| .::.||:|            :.|.|:.:  |...|:
Zfish   317 LP-----RPAAELFQSQQFNKVP-LMTGVTDD------------EIGFVLPNYLLPPDWINGLDL 363

  Fly   367 -ELAPYLLFYRDTKTKKDMDDYS--RKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDL 428
             .:.|.|..:...     :.|.|  ..:..||:|.....|......:.:..|.:|....:::...
Zfish   364 ESILPLLTVFNPA-----LQDQSVLELLLNEYLGTSPDRIRIRDGFREMLGDFMFNIPARQTASY 423

  Fly   429 HRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIF------------ENFVRDV 481
            ||..| :|.|.|.:.:|     ..||..:.....|:.|||:...:|            ||
Zfish   424 HRDAG-APVYVYEFRHP-----PSVLQRKRPSFSGSDHGDEIVFVFGYCFSEGPIGMAEN----- 477

  Fly   482 EMRPDEQIISRNFINMLADFASSDN 506
             :..:|..:.|..:....:||.:.|
Zfish   478 -LSDEEDELCRTTMAYWGNFAHTGN 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	153/525 (29%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	62/139 (45%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613	155/529 (29%)
		COesterase	553..1065	CDD:306613
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910