DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-6 and nlgn2a

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_009301340.1	Gene:	nlgn2a / 556158	ZFINID:	ZDB-GENE-090918-2	Length:	828	Species:	Danio rerio

Alignment Length:	529	Identity:	146/529 - (27%)
Similarity:	206/529 - (38%)	Gaps:	112/529 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LWLGSNASDTDDP----LLVQLPQGKLRGRDN-------GSYYSYESIPYAEPPTGDLRFEAPEP 68
            ||:...:....||    ..|....|||||...       |....|..:|||..|.||.||:.||.
Zfish    30 LWITLASCQRIDPGTKYPTVTTNYGKLRGIKKELNNEILGPVEQYLGVPYATAPIGDRRFQPPEA 94

  Fly    69 YKQKWSDIFDATKTPVACLQ-------------W--DQFTPGANKLVGE-EDCLTVSVYKPKNS- 116
             ...|.::.:||:....|.|             |  |.....|..:..: ||||.::||.|...
Zfish    95 -PGSWQEVRNATQFAPVCPQNVHGVLPEIMLPVWFTDSLDVAATYIQNQSEDCLYLNVYVPTEDG 158

  Fly   117 --------------------KRNSFPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLG 161
                                .|...||:..||||::|.|.........:...|..|:|.::||||
Zfish   159 PLTKKHDESTLNRPRDEDIRDRRKKPVMLFIHGGSYMEGTGNMFDASVLAAYGNVIVVTMNYRLG 223

  Fly   162 PLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQ 226
            .|||:||||:...|||||.||..||:|:.:||..|||:|:.:.:.|..||.:.|:|.:|......
Zfish   224 VLGFLSTGDQSAKGNYGLLDQIQALRWLNENIGHFGGDPERITIFGSGAGASCVNLLILSHHSEG 288

  Fly   227 LARAAFSFSGNALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELV---TAVRK 288
            |.:.|.:.||:|:..|.|..........|.|.|||...| :..|..||:.|...|||   ....:
Zfish   289 LFQRAIAQSGSAISSWSISYQPLKYTKILARKVGCTYGE-TADLVDCLRRKNFRELVDQDIQPAR 352

  Fly   289 FLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKF-----------GQVPWAVSYVTEDGG 342
            :.|       .|.||::....||     ||..:::.|:|           |:   .:.:| :|||
Zfish   353 YHI-------AFGPVMDGDVVPD-----DPEILMQQGEFLNYDLLIGVNQGE---GLKFV-DDGG 401

  Fly   343 YNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYI-------GNQR 400
                   .|.:.||.....:.........|..|     .|..|.....||..|.       |..|
Zfish   402 -------TESEEGISAAAFDYTISNFVDNLYGY-----PKGKDILRETIKFMYTDWADRDNGEMR 454

  Fly   401 FDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTV 465
                 ...|..||||..:......:..||..| :||.|.|.:.:..:.......|:       ..
Zfish   455 -----RKTLLALFTDHQWVAPAIATAKLHADY-QSPVYFYTFYHHCQTETRPEWAD-------AA 506

  Fly   466 HGDDYFLIF 474
            |||:...:|
Zfish   507 HGDEIPYVF 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	142/511 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	53/153 (35%)
nlgn2a	XP_009301340.1	COesterase	47..608	CDD:306613	142/512 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575540
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740