Protein Alignment Est-6 and NLGN3

DIOPT Version :9

• Sequence 1: NP_001261749.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 150/549 - (27%)
• Similarity: 218/549 - (39%)
• Gaps: 113/549 - (20%)

  Fly     4 VGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRG-------RDNGSYYSYESIPYAEPPTGDL 61
            ||..|.:.|..|.|...||.......|....|||||       ...|....|..:|||.||.|:.
Human    18 VGRSLCLTLWFLSLALRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEK 82

  Fly    62 RFEAPEPYKQKWSDIFDATKTPVACLQ-------------WDQFTPGANKLV-----GEEDCLTV 108
            ||..||| ...||.|.:||..|..|.|             |  ||...:.:.     ..||||.:
Human    83 RFLPPEP-PPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVW--FTANLDIVATYIQEPNEDCLYL 144

  Fly   109 SVYKP-------------KNSKR------------------------------NSFPVVAHIHGG 130
            :||.|             |.:|:                              .:.||:.:||||
Human   145 NVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGG 209

  Fly   131 AFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIAS 195
            ::|.|.........:...|..|::.::||:|.|||:||||:...|||||.||..||:|:.:|||.
Human   210 SYMEGTGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAF 274

  Fly   196 FGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVG 260
            |||:|:.:.:.|...|.:.|.|..|......|.:.|...||:||..|.:..........|...||
Human   275 FGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVG 339

  Fly   261 CESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVP---FAPFSPVLEPSDAPDAIITQDPRDVI 322
            | :..|:..:..||:.|.|.|||..       ...|   ...|.||::....||     ||..::
Human   340 C-NVLDTVDMVDCLRQKSAKELVEQ-------DIQPARYHVAFGPVIDGDVIPD-----DPEILM 391

  Fly   323 KSGKFGQVPWAVSY-----VTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKTKK 382
            :.|:|      ::|     |.:..|......:.:.:.|:...|.:.........|..|.:.|
Human   392 EQGEF------LNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGK--- 447

  Fly   383 DMDDYSRKIKQEYIG-NQRFDIESYSE-LQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNP 445
              |.....||..|.. ..|.:.|:..: |..||||..:...:..:.|||.:|| ||.|.|.:.:.
Human   448 --DTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYG-SPTYFYAFYHH 509

  Fly   446 AEKGIAQVLANRTDYDFGTVHGDDYFLIF 474
            .:..:....::       ..|||:...:|
Human   510 CQSLMKPAWSD-------AAHGDEVPYVF 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	142/524 (27%)
		Aes	<110..>243	CDD:223730	53/175 (30%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	143/531 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142569
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740