Protein Alignment Est-6 and Ces2h

DIOPT Version :9

• Sequence 1: NP_001261749.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_001258974.1
• Gene: Ces2h / 436059
• MGIID: 3648740
• Length: 558
• Species: Mus musculus
• Alignment Length: 542
• Identity: 151/542 - (27%)
• Similarity: 244/542 - (45%)
• Gaps: 101/542 - (18%)

  Fly     7 GLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGR-------DNGSYYSYESIPYAEPPTGDLRFE 64
            ||:::|..     ...|:..|:.. ...|::.|.       |.| .:|:..||:|:||.|.|||.
Mouse    16 GLLLLLRV-----QGQDSTSPIRT-THTGQILGSLIHMKDLDVG-VHSFLGIPFAKPPVGPLRFA 73

  Fly    65 APEPYKQKWSDIFDATKTPVACLQ-WDQFTPGANKLVG--------EEDCLTVSVYKPKNSKRNS 120
            .||| .:.|..:.|.|..|..||| .......|.||:.        .||||.:::|.|.::...|
Mouse    74 PPEP-PEPWGGVRDGTSHPAMCLQDITAMNMQAFKLLKLTLPPFPMSEDCLYLNIYAPDHAHEGS 137

  Fly   121 -FPVVAHIHGGAFMFG-AAWQNGH-----ENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYG 178
             .||:..||||:.:.| |:..:|.     |||      ::|.|.||||.|||.||||....||:|
Mouse   138 NLPVMVWIHGGSLVIGMASMYDGSMLAAMENV------VVVTIQYRLGVLGFFSTGDERARGNWG 196

  Fly   179 LKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWV 243
            ..||..||:|::||||.|||.|..|.:.|.||||.||...::......|.|.|...||.||...:
Mouse   197 YLDQVAALRWLQQNIAYFGGNPDRVTIFGTSAGGTSVSSLVVSPMSQGLFRGAIMESGVALISSL 261

  Fly   244 IQKGARGRAFELGRNV-GCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPS 307
            |...: ...::...|: |||.. ||.:|..||:.|...|::...:.|.|.             |.
Mouse   262 ISVSS-DVVYQTVANLSGCEQV-DSEALVNCLRGKSEEEIMAINKAFKII-------------PG 311

  Fly   308 DAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGY--NAALLLKERKSGIVIDDLNERWLELAP 370
            ......:.:.|::::.|..|..||..:....::.|:  .:::.:.:.|.|:      :|  ::..
Mouse   312 IVDGIFLPRHPQELMASADFHPVPSIIGVNNDEYGWIIPSSMSMIDSKKGM------DR--QMVQ 368

  Fly   371 YLLFYRDTKTKKDMDDYSRKIKQEYIGNQ---RFDIESYSELQRLFTDIL-------FKNSTQES 425
            .:|..|.|:.... .:.|..:.:||:|:.   :|....:.|:.:.||.::       |:.|
Mouse   369 AILQRRATQMMWP-PEVSDLLMEEYMGDNEDPQFLQVQFKEMMKDFTFVIPALQVAQFQRS---- 428

  Fly   426 LDLHRKYGKSPAYAYVYDN-PA---EKGIAQVLANRTDYDFGTVHGDDYFLIFENF--VRDVEMR 484
                    .:|.:.|.:.: |:   :...:.|.|:         |||:...||.:|  ...|:..
Mouse   429 --------HAPVFFYEFQHRPSFFKDSKPSHVKAD---------HGDEILFIFRSFWGGTQVDFT 476

  Fly   485 PDEQIISRNFINMLADFASSDN 506
            .:|:::||..:...|:||...|
Mouse   477 EEEELLSRRMMKYWANFARQRN 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	146/520 (28%)
		Aes	<110..>243	CDD:223730	59/139 (42%)
Ces2h	NP_001258974.1	COesterase	30..537	CDD:278561	147/523 (28%)
		Aes	<127..>230	CDD:223730	48/108 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832784
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840