DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Est-6 and ACHE

DIOPT Version :9

Sequence 1:NP_001261749.1 Gene:Est-6 / 39392 FlyBaseID:FBgn0000592 Length:544 Species:Drosophila melanogaster
Sequence 2:NP_001354847.1 Gene:ACHE / 43 HGNCID:108 Length:681 Species:Homo sapiens


Alignment Length:555 Identity:161/555 - (29%)
Similarity:253/555 - (45%) Gaps:118/555 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 IVLSCLWL---GSNASDTDD-PLLVQLPQGKLRG----RDNGSYYSYESIPYAEPPTGDLRFEAP 66
            ::|..|||   |..|...:| .|||.:..|:|||    ...|...::..||:||||.|..||..|
Human    84 LLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPP 148

  Fly    67 EPYKQKWSDIFDATKTPVACLQW-DQFTPG--------ANKLVGEEDCLTVSVYKPKNSKRNSFP 122
            || ||.||.:.|||.....|.|: |...||        .|:.: .||||.::|:.|.....:..|
Human   149 EP-KQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNREL-SEDCLYLNVWTPYPRPTSPTP 211

  Fly   123 VVAHIHGGAFMFGAAWQNGHEN--VMREGKFILVKISYRLGPLGFVS-TGDRDLPGNYGLKDQRL 184
            |:..|:||.|..||:..:.::.  :::..:.:||.::||:|..||:: .|.|:.|||.||.||||
Human   212 VLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRL 276

  Fly   185 ALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPW-VIQKG- 247
            ||:|:::|:|:|||:|.:|.|.|.|||.|||.:.:|......|...|...||....|| .:..| 
Human   277 ALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGE 341

  Fly   248 ARGRAFELGRNVGCE---SAEDSTSLKKCLKSKPASELVT----AVRKFLIFSYVPFAPFSPVLE 305
            ||.||.:|...|||.   :..:.|.|..||:::||..||.    .:.:..:|.:    .|.||::
Human   342 ARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRF----SFVPVVD 402

  Fly   306 P---SDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLE 367
            .   ||.|:|:        |.:|.|..:...|..|.::|.|                        
Human   403 GDFLSDTPEAL--------INAGDFHGLQVLVGVVKDEGSY------------------------ 435

  Fly   368 LAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQR-----LFTDILFKNS---TQE 424
               :|::.....:|   |:.|...:.|::...|..:...|:|..     .:||.|....   .:|
Human   436 ---FLVYGAPGFSK---DNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLRE 494

  Fly   425 SLD-----------LHRKYGKSPA-----YAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLI 473
            :|.           :.:..|:..|     ||||:::.|.. ::..|.      .|..||.:...|
Human   495 ALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRAST-LSWPLW------MGVPHGYEIEFI 552

  Fly   474 FENFVRDVEMRP------DEQIISRNFINMLADFA 502
            |     .:.:.|      :|:|.::..:...|:||
Human   553 F-----GIPLDPSRNYTAEEKIFAQRLMRYWANFA 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Est-6NP_001261749.1 Esterase_lipase 29..537 CDD:238191 153/532 (29%)
Aes <110..>243 CDD:223730 53/136 (39%)
ACHENP_001354847.1 COesterase 104..630 CDD:395084 154/535 (29%)
AChE_tetra 645..678 CDD:400834
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142702
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000017
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11559
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.940

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