DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Ace

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	147/579 - (25%)
Similarity:	249/579 - (43%)	Gaps:	116/579 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGR----DNGSYYSYESIPYAEPPTGDLRFE 64
            :.|.|::||| |.| |......|.|:||...|.:|||    .....:.|..||||:||..||||.
  Fly    21 IPLPLVLVLS-LHL-SGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFR 83

  Fly    65 APEPYKQKWSDIFDATKTPVACLQ--WDQFTPGANKLVGE----------EDCLTVSVYKP---- 113
            .|.| .:.|..:.|||:....|:|  ::.| ||.:   ||          ||||.::|:.|
  Fly    84 KPVP-AEPWHGVLDATRLSATCVQERYEYF-PGFS---GEEIWNPNTNVSEDCLYINVWAPAKAR 143

  Fly   114 ------------KNSKR----------------NSFPVVAHIHGGAFMFGAAWQNGHE-NVMRE- 148
                        .|.|:                |..|::..|:||.||.|:|..:.:. ::|..
  Fly   144 LRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAV 208

  Fly   149 GKFILVKISYRLGPLGFV-------STGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLV 206
            |..|:....||:|..||:       |....:.|||.||.||.||::|:|.|..:|||.|:.:.|.
  Fly   209 GNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLF 273

  Fly   207 GHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGR----NVGCESAEDS 267
            |.|||.:||:.|::......|.:.....||....||  ......:|.|:|:    :..|.::...
  Fly   274 GESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPW--SHMTSEKAVEIGKALINDCNCNASMLK 336

  Fly   268 TS---LKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQ 329
            |:   :..|::|..|..:  :|:::..:|.:...|.:|.::     .|.:..||..::|:.....
  Fly   337 TNPAHVMSCMRSVDAKTI--SVQQWNSYSGILSFPSAPTID-----GAFLPADPMTLMKTADLKD 394

  Fly   330 VPWAVSYVTEDGGYNAALLLKERKSGIVIDDL----NERWLELAPYLLFYRDTKTKKD--MDDYS 388
            ....:..|.::|.|   .||.:.......||.    .:::||:... :|.:.|:.:::  :..|:
  Fly   395 YDILMGNVRDEGTY---FLLYDFIDYFDKDDATALPRDKYLEIMNN-IFGKATQAEREAIIFQYT 455

  Fly   389 RKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKGIAQV 453
                 .:.||..:  ::..::.|...|..|...|.|......:.|.|..|.|
  Fly   456 -----SWEGNPGY--QNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYY------------- 500

  Fly   454 LANRTDYD-----FGTVHGDDYFLIF-ENFVRDVEMRPDEQIISRNFINMLADFASSDN 506
            ..:||...     .|.:|||:....| :.....::.||.|:.:.:..::.:.:||.:.|
  Fly   501 FTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGN 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	137/554 (25%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	50/173 (29%)
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	139/557 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440346
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840