DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and CG4757

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	155/566 - (27%)
Similarity:	248/566 - (43%)	Gaps:	107/566 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LIIVLSCLWLGSNAS----DTDDPLLVQLPQGKLRG-----RDNGSYYSYESIPYAEPPTGDLRF 63
            ::.|:..|.|.:::|    :.|..|      |::||     |...:::::..|.|||||.|||||
  Fly     3 MLFVVELLVLLASSSVLSIEVDTEL------GRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRF 61

  Fly    64 EAPEPYKQKWS-DIFDATKTPVACLQ-WDQFTPGANKLVGEEDCLTVSVY-KPKNSKRNSFPVVA 125
            ..|:|.| .|| .||||::....|.| ||..|..:      ||||.::|| |....:|   ||:.
  Fly    62 VNPQPVK-PWSPKIFDASEDGPMCPQPWDNMTDVS------EDCLRLNVYTKDLKGRR---PVIV 116

  Fly   126 HIH-GGAFMFG--AAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALK 187
            .:| ||.::|.  :.:..|.|:.| :...:||.::||||.|||::||.::.|||.|||||.|||:
  Fly   117 FLHPGGFYVFSGQSKYLAGPEHFM-DRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALR 180

  Fly   188 WIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAF--------------SFSGNA 238
            ||:|:|..|||:|.:|.|:|:|||..||.|.||    ..::|..|              .:..|.
  Fly   181 WIQQHIQRFGGDPDSVTLLGYSAGSISVALHML----SPMSRGLFHRGICMSAAPYGPVKYKDND 241

  Fly   239 LDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPV 303
            |.....|.|.          :.|.. |....:.:|::.||..:.|:.......|.:.|...:..|
  Fly   242 LQLAKRQAGL----------LKCPQ-ESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIV 295

  Fly   304 LEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLEL 368
            :|.....:..:.:.|....:.|.|.:|. .::.:||....:.|..  :.::..:::..|..|...
  Fly   296 VEKDFGQERYLIESPFKTARRGDFHKVA-LITGITEFEFLSGAFF--DLRNESIVNRYNRDWEHY 357

  Fly   369 APYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIE---SYSELQRLFTDILFKNSTQESLDLHR 430
            |...|......|:...  .||..:::|:......:|   |...:..|.:|.|...|....|.|..
  Fly   358 ASIALLLEQNSTQSRA--ASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQLMS 420

  Fly   431 KYGKSPAYAYVYDNPAEKGIAQVLANRTDYD-FGTVHGDDYFLIF--------------ENFV-- 478
            .:  :|.|.|::   ..||....|.|..:.. .|.||.|:...:|              |||:
  Fly   421 PH--TPIYTYLF---RYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKREDPENFMIE 480

  Fly   479 ------------RDVEMRPDEQIISRNFINMLADFASSDNGSLKYG 512
                        .|...:.||.:...|:    ..:.:.|.|.|:.|
  Fly   481 LLTRMWIEFAQKGDPHNKNDEYLKGLNW----PLYNAQDKGYLEIG 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	149/541 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	58/150 (39%)
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	152/554 (27%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	76/174 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440348
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25788
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.900